Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Genes Polymorphisms and Their Association with COVID-19 Severity in Children

Kateryna Kozak
* ORCID logo ,
Halyna Pavlyshyn
ORCID logo ,
Aleksandr Kamyshnyi
,
Oksana Shevchuk
ORCID logo ,
Mykhaylo Korda
ORCID logo ,
Sandor G. Vari
Version 1 : Received: 8 September 2023 / Approved: 11 September 2023 / Online: 12 September 2023 (02:56:04 CEST)

A peer-reviewed article of this Preprint also exists.

Kozak, K.; Pavlyshyn, H.; Kamyshnyi, O.; Shevchuk, O.; Korda, M.; Vari, S.G. The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism. Viruses 2023, 15, 2093. Kozak, K.; Pavlyshyn, H.; Kamyshnyi, O.; Shevchuk, O.; Korda, M.; Vari, S.G. The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism. Viruses 2023, 15, 2093.

Abstract

Coronavirus disease (COVID-19) and its outcomes remain one of the most challenging problems today. COVID-19 in children could be asymptomatic but can result in a fatal outcome, therefore, prediction of the disease severity is important. The goal was to investigate the human genetic factors that could be associated with COVID-19 severity in children. Single nucleotide polymor-phisms of the following genes were studied: ACE2 (rs2074192), IFNAR2 (rs2236757), TYK2 (rs2304256), OAS1 (rs10774671), OAS3 (rs10735079), CD40 (rs4813003), FCGR2A (rs1801274) and CASP3 (rs113420705). In the case-control study were 30 children with mild or moderate course of the disease; 30 with severe COVID-19 symptoms and multisystem inflammatory syndrome in children (MIS -C) and 15 healthy who did not have COVID-19 infection (PCR negative, Ig G negative). The study revealed that ACE2 rs2074192 (allele T), IFNAR2 rs2236757 (allele A), OAS1 rs10774671 (allele A), CD40 rs4813003 (allele C), CASP3 rs113420705 (allele C) and male sex contribute to severe course COVID-19 infection, and MIS-C in 85.6% of cases. The World Health Organization reported new COVID-19 variants may cause previously unseen symptoms in chil-dren. Although the study has limitation due to cohort size, the findings can help provide a better understanding of SARS-CoV-2 infection and proactive pediatric patient management.

Keywords

ACE2; IFNAR2; TYK2; OAS1; OAS3; CD40; FCGR2A; CASP3, COVID-19; children

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.