Essay
Version 1
Preserved in Portico This version is not peer-reviewed
Throwing Good Money, and Millions of Lives, after Bad
Version 1
: Received: 7 September 2023 / Approved: 11 September 2023 / Online: 11 September 2023 (12:39:50 CEST)
How to cite: Triunfol, M. Throwing Good Money, and Millions of Lives, after Bad. Preprints 2023, 2023090705. https://doi.org/10.20944/preprints202309.0705.v1 Triunfol, M. Throwing Good Money, and Millions of Lives, after Bad. Preprints 2023, 2023090705. https://doi.org/10.20944/preprints202309.0705.v1
Abstract
Escalation of commitment explains the choice for investing in an option for which great investments have previously been made even though better choices became available. The last 25 years of producing innumerous versions of Alzheimer Disease animal models with virtually no predictive validity should have exposed the fact that using animals for studying AD is clearly a failing course of action and as such should have been abandoned long ago, giving room to other alternatives to flourish. In this assay, I explore the idea that the investment in new animal models for studying Alzheimer (AD) represents a classic case of escalation of commitment, and sunk cost dilemma, in the biomedical research.
Keywords
escalation of commitment; sunk cost; Alzheimer Disease; animal models
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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