Review
Version 1
Preserved in Portico This version is not peer-reviewed
Role of Akt/Protein Kinase B in Cancer Metastasis
Version 1
: Received: 8 September 2023 / Approved: 11 September 2023 / Online: 12 September 2023 (08:33:01 CEST)
A peer-reviewed article of this Preprint also exists.
Islam, M.; Jones, S.; Ellis, I. Role of Akt/Protein Kinase B in Cancer Metastasis. Biomedicines 2023, 11, 3001. Islam, M.; Jones, S.; Ellis, I. Role of Akt/Protein Kinase B in Cancer Metastasis. Biomedicines 2023, 11, 3001.
Abstract
Metastasis is a critical step in the process of carcinogenesis and a vast majority of cancer related mortalities result from metastat-ic disease that is resistant to current therapies. Cell migration and invasion are the first steps of the metastasis process, which mainly occurs by two important biological mechanisms i.e., cytoskeletal remodelling and Epithelial to Mesenchymal Transition (EMT). Akt (also known as Protein Kinase B) is a central signalling molecule of the PI3K-Akt signalling pathway. Aberrant acti-vation of this pathway has been identified in a wide range of cancers. Several studies have revealed that Akt actively engages with the migratory process in motile cells, including metastatic cancer cells. The downstream signalling mechanism of Akt in cell migration depends upon the tumour type, sites, and intracellular localisation of activated Akt. In this review, we focus on the role of Akt in the regulation of two events that control cell migration and invasion in various cancers including head and neck squamous cell carcinoma (HNSCC) and the status of PI3K-Akt pathway inhibitors in clinical trials in HNSCC.
Keywords
Akt; cancer; metastasis; HNSCC; EMT; cytoskeletal remodelling
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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