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PET-CT spectrum of large vessel vasculitis (LVV) in a tertiary center: differences in FDG uptake between LVV with predominant cranial and extracranial giant cell arteritis phenotypes
Heras-Recuero, E.; Landaeta-Kancev, L.C.; Martínez de Bourio-Allona, M.; Torres-Rosello, A.; Blázquez-Sánchez, T.; Ferraz-Amaro, I.; Castañeda, S.; Martínez-López, J.A.; Martínez-Dhier, L.; Largo, R.; González-Gay, M.Á. Positron Emission Computed Tomography Spectrum of Large Vessel Vasculitis in a Tertiary Center: Differences in 18F-fluorodeoxyglucose Uptake between Large Vessel Vasculitis with Predominant Cranial and Extracranial Giant Cell Arteritis Phenotypes. J. Clin. Med.2023, 12, 6164.
Heras-Recuero, E.; Landaeta-Kancev, L.C.; Martínez de Bourio-Allona, M.; Torres-Rosello, A.; Blázquez-Sánchez, T.; Ferraz-Amaro, I.; Castañeda, S.; Martínez-López, J.A.; Martínez-Dhier, L.; Largo, R.; González-Gay, M.Á. Positron Emission Computed Tomography Spectrum of Large Vessel Vasculitis in a Tertiary Center: Differences in 18F-fluorodeoxyglucose Uptake between Large Vessel Vasculitis with Predominant Cranial and Extracranial Giant Cell Arteritis Phenotypes. J. Clin. Med. 2023, 12, 6164.
Heras-Recuero, E.; Landaeta-Kancev, L.C.; Martínez de Bourio-Allona, M.; Torres-Rosello, A.; Blázquez-Sánchez, T.; Ferraz-Amaro, I.; Castañeda, S.; Martínez-López, J.A.; Martínez-Dhier, L.; Largo, R.; González-Gay, M.Á. Positron Emission Computed Tomography Spectrum of Large Vessel Vasculitis in a Tertiary Center: Differences in 18F-fluorodeoxyglucose Uptake between Large Vessel Vasculitis with Predominant Cranial and Extracranial Giant Cell Arteritis Phenotypes. J. Clin. Med.2023, 12, 6164.
Heras-Recuero, E.; Landaeta-Kancev, L.C.; Martínez de Bourio-Allona, M.; Torres-Rosello, A.; Blázquez-Sánchez, T.; Ferraz-Amaro, I.; Castañeda, S.; Martínez-López, J.A.; Martínez-Dhier, L.; Largo, R.; González-Gay, M.Á. Positron Emission Computed Tomography Spectrum of Large Vessel Vasculitis in a Tertiary Center: Differences in 18F-fluorodeoxyglucose Uptake between Large Vessel Vasculitis with Predominant Cranial and Extracranial Giant Cell Arteritis Phenotypes. J. Clin. Med. 2023, 12, 6164.
Abstract
Objective: To assess the spectrum of PET-CT-related large vessel vasculitis (LVV) in a Spanish tertiary center and to determine whether FDG uptake by PET-CT differs between giant cell arteritis (GCA) with predominant cranial or extracranial phenotypes.
Methods: The spectrum of patients diagnosed with LVV by PET-CT in a tertiary referral hospital that cares for 450,000 people over a period of two years was reviewed. Moreover, differences in FDG uptake between LVV-GCA with predominantly cranial and extracranial phenotype were analyzed.
Results: Eighty patients were diagnosed with LVV by PET-CT. Most were due to systemic vasculitis (n=64; 80%), especially GCA (n=54; 67.5%). Other conditions included the presence of rheumatic diseases (n=4; 3.2%), tumors (n=9; 7.2%), and infections (n=3; 2.4%). LVV-GCA patients with predominant extracranial GCA phenotype were younger (mean ± SD: 68.07 ± 9.91 versus 75.46 ± 7.64 years; p= 0.017) and had a longer delay to the diagnosis (median [interquartile range] 12 [4-18] versus 4 [3-8]; p=0.006), but had PMR symptoms more frequently than those with predominantly cranial GCA phenotype (46.3% versus 15.4%, p= 0.057). When FDG uptake was compared according to the two different disease patterns, no statistically significant differences were observed. However, patients with extracranial LVV-GCA showed a non-significantly higher frequency of vasculitic involvement of lower extremity arteries.
Conclusion: Regardless of the predominant phenotype, LVV identified by PET-CT is more commonly due to GCA in the Spanish population. In these GCA patients, younger age, PMR and a higher frequency of lower extremity artery vasculitis suggest the presence of LVV.
Keywords
Positron emission computed tomography (PET-CT) with 18F-fluorodeoxyglucose (FDG), large vessel vasculitis, vasculitis, giant cell arteritis, polymyalgia rheumatica
Subject
Medicine and Pharmacology, Internal Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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