Khamis, A.; Salzer, L.; Schiegnitz, E.; Stauber, R.H.; Gül, D. The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy. Int. J. Mol. Sci.2023, 24, 15058.
Khamis, A.; Salzer, L.; Schiegnitz, E.; Stauber, R.H.; Gül, D. The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy. Int. J. Mol. Sci. 2023, 24, 15058.
Khamis, A.; Salzer, L.; Schiegnitz, E.; Stauber, R.H.; Gül, D. The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy. Int. J. Mol. Sci.2023, 24, 15058.
Khamis, A.; Salzer, L.; Schiegnitz, E.; Stauber, R.H.; Gül, D. The Magic Triangle in Oral Potentially Malignant Disorders: Vitamin D, Vitamin D Receptor, and Malignancy. Int. J. Mol. Sci. 2023, 24, 15058.
Abstract
OPMDs (Oral Potentially Malignant Disorders) are a group of disorders affecting the oral mucosa that are characterized by aberrant cell proliferation and a higher risk of malignant transformation. Vitamin D (VitD) and its receptor (VDR) have been extensively studied for their potential contributions to the prevention and therapeutic management of a range of diseases and neoplastic conditions, including oral cancer. Observational studies suggest correlations between VitD deficiency and higher cancer risk, worse prognosis, and increased mortality rates. Interestingly, emerging data also reveals a link between VitD insufficiency and the onset or progression of OPMDs. Understanding the role of the VitD-VDR axis not only in established oral tumors but also in OPMDs might thus enable early detection and prevention of malignant transformation. With this article, we want to provide an overview of current knowledge about OPMDs and VitD, and investigate their potential association and ramifications for clinical management of OPMDs.
Keywords
VitD; VitD receptor; OPMD; SCC; premalignancy; white lesions; red lesions
Subject
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
