Comparative Cytotoxic Study of Wild Plant Extracts, Their Callus Cultures and 2,3-Dihidrobenzofuran from Ageratina pichinchensis

Mariana Sánchez‒Ramos; José Guillermo Encarnación‒García; Silvia Marquina Bahena; Jessica Nayelli Sánchez-Carranza; Antonio Bernabé Antonio; Valeri Domínguez-Villegas; Emmanuel Cabañas-García; Francisco Cruz Sosa

doi:10.20944/preprints202309.0360.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202309.0360.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Comparative Cytotoxic Study of Wild Plant Extracts, Their Callus Cultures and 2,3-Dihidrobenzofuran from Ageratina pichinchensis

Mariana Sánchez‒Ramos

^* ,

José Guillermo Encarnación‒García

Silvia Marquina Bahena

Jessica Nayelli Sánchez-Carranza

Antonio Bernabé Antonio

Valeri Domínguez-Villegas

Emmanuel Cabañas-García

Francisco Cruz Sosa

Version 1 : Received: 4 September 2023 / Approved: 5 September 2023 / Online: 6 September 2023 (03:51:03 CEST)

A peer-reviewed article of this Preprint also exists.

Sánchez-Ramos, M.; Encarnación-García, J.G.; Marquina-Bahena, S.; Sánchez-Carranza, J.N.; Bernabé-Antonio, A.; Domínguez-Villegas, V.; Cabañas-García, E.; Cruz-Sosa, F. Cytotoxic Activity of Wild Plant and Callus Extracts of Ageratina pichinchensis and 2,3-Dihydrobenzofuran Isolated from a Callus Culture. Pharmaceuticals 2023, 16, 1400. Sánchez-Ramos, M.; Encarnación-García, J.G.; Marquina-Bahena, S.; Sánchez-Carranza, J.N.; Bernabé-Antonio, A.; Domínguez-Villegas, V.; Cabañas-García, E.; Cruz-Sosa, F. Cytotoxic Activity of Wild Plant and Callus Extracts of Ageratina pichinchensis and 2,3-Dihydrobenzofuran Isolated from a Callus Culture. Pharmaceuticals 2023, 16, 1400.

Abstract

: The cytotoxic effect of four extracts obtained from the wild plant and two from a culture of Ag-eratina pichinchensis calluses on cell lines: prostate carcinoma, cervical cancer, hepatocellular car-cinoma, human hepatoma, lung cancer and cellular keratinocytes was evaluated; the extracts were obtained with ethyl acetate and methanol, leaves and stems were used from the wild plant. The results of the cytotoxic evaluation showed that only the ethyl acetate extract obtained from the callus culture showed an effect on the cervical cancer cell line (HeLa) with an IC50 of 94.79 ± 2.0 µg/mL. The purification of this extract allowed obtaining a benzofuran type compound as the main product, which was identified as 2,3-dihydrobenzofuran. The cytotoxic evaluation of this compound showed an important effect against the HeLa cell line with an IC50 of 23.86 ± 2. .5µg/mL. These results contribute to the development of alternatives for the production of com-pounds for the treatment of cancer.

Keywords

ytotoxic activity; 2,3-dihydrobenzofuran; cervical cancer

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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