Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review

Ayesha Zafar Iqbal
,
Suet-Kei Wu
ORCID logo ,
Halliru Zailani
ORCID logo ,
Wei-Che Chiu
,
Wen-Chun Liu
ORCID logo ,
Kuan-Pin Su
* ,
Shin-Da Lee
*
Version 1 : Received: 1 September 2023 / Approved: 1 September 2023 / Online: 4 September 2023 (03:56:14 CEST)

A peer-reviewed article of this Preprint also exists.

Iqbal, A.Z.; Wu, S.-K.; Zailani, H.; Chiu, W.-C.; Liu, W.-C.; Su, K.-P.; Lee, S.-D. Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review. Nutrients 2023, 15, 4231. Iqbal, A.Z.; Wu, S.-K.; Zailani, H.; Chiu, W.-C.; Liu, W.-C.; Su, K.-P.; Lee, S.-D. Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review. Nutrients 2023, 15, 4231.

Abstract

The menopausal transition often accompanies distressing manifestations, including vasomotor symptoms, sleep disruptions, and depressive syndrome. Omega-3 fatty acids have emerged as a potential intervention to alleviate these symptoms. This review aimed to comprehensively assess the impact of omega-3 supplementation on vasomotor symptoms, sleep quality, and depression among postmenopausal women. We conducted a systematic search focusing on randomized control trials across the Cochrane Library, Web of Science, PubMed, CINAHL, EMBASE, and SCOPUS databases from inception to August 2023. Among the initial pool of 163 studies, 9 studies met the inclusion criteria and were incorporated into this review. Four studies suggested potential benefits of omega-3 intake for improving hot flashes and night sweats. Sleep quality outcomes displayed heterogeneity across the studies. Incorporating diverse scales such as the Hamilton Depression Rating Scale-21, the Patient Health Questionnaire depression scale, and Generalized Anxiety Disorder-7 for depression outcomes, the review found inconclusive evidence on omega-3's impact on depression. Overall, the combined analysis of these studies did not provide substantial evidence to support the efficacy of omega-3 fatty acids in improving vasomotor symptoms, sleep quality, and depression. Further well-designed RCTs with larger participant groups are crucial to validate and generalize these results.

Keywords

amenorrhea; depression; hot flashes; omega-3 PUFA; post-menopause; sleep quality; vasomotor symptoms

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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