Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Payel Kundu; Kanon Yasuhara; Mikah S Brandes; Jonathan A Zweig; Cody J Neff; Sarah Holden; Kat Kessler; Steven Matsumoto; Halina Offner; Carin S Waslo; Arthur Vandenbark; Amala Soumyanath; Larry S Sherman; Jacob Raber; Nora E Gray; Rebecca I Spain

doi:10.20944/preprints202309.0013.v1

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preprints.org > medicine and pharmacology > neuroscience and neurology > doi: 10.20944/preprints202309.0013.v1

Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Version 1 : Received: 30 August 2023 / Approved: 31 August 2023 / Online: 1 September 2023 (13:04:45 CEST)

How to cite: Kundu, P.; Yasuhara, K.; Brandes, M.S.; Zweig, J.A.; Neff, C.J.; Holden, S.; Kessler, K.; Matsumoto, S.; Offner, H.; Waslo, C.S.; Vandenbark, A.; Soumyanath, A.; Sherman, L.S.; Raber, J.; Gray, N.E.; Spain, R.I. Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis. Preprints 2023, 2023090013. https://doi.org/10.20944/preprints202309.0013.v1 Kundu, P.; Yasuhara, K.; Brandes, M.S.; Zweig, J.A.; Neff, C.J.; Holden, S.; Kessler, K.; Matsumoto, S.; Offner, H.; Waslo, C.S.; Vandenbark, A.; Soumyanath, A.; Sherman, L.S.; Raber, J.; Gray, N.E.; Spain, R.I. Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis. Preprints 2023, 2023090013. https://doi.org/10.20944/preprints202309.0013.v1

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MDPI and ACS Style

Kundu, P.; Yasuhara, K.; Brandes, M.S.; Zweig, J.A.; Neff, C.J.; Holden, S.; Kessler, K.; Matsumoto, S.; Offner, H.; Waslo, C.S.; Vandenbark, A.; Soumyanath, A.; Sherman, L.S.; Raber, J.; Gray, N.E.; Spain, R.I. Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis. Preprints 2023, 2023090013. https://doi.org/10.20944/preprints202309.0013.v1

APA Style

Kundu, P., Yasuhara, K., Brandes, M.S., Zweig, J.A., Neff, C.J., Holden, S., Kessler, K., Matsumoto, S., Offner, H., Waslo, C.S., Vandenbark, A., Soumyanath, A., Sherman, L.S., Raber, J., Gray, N.E., & Spain, R.I. (2023). Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis. Preprints. https://doi.org/10.20944/preprints202309.0013.v1

Chicago/Turabian Style

Kundu, P., Nora E Gray and Rebecca I Spain. 2023 "Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis" Preprints. https://doi.org/10.20944/preprints202309.0013.v1

Abstract

Centella asiatica (Centella) is a traditional botanical medicine that shows promise in treating dementia based on behavioral alterations seen in animal models of aging and cognitive dysfunction. In order to determine if Centella could similarly improve cognitive function and reduce disease burden in multiple sclerosis (MS), we tested its effects in the neuroinflammatory experimental autoimmune encephalomyelitis (EAE) model of MS. In two independent experiments, C57BL/6J mice were treated following induction of EAE with either a standardized water extract of Centella (CAW) or placebo for 2 weeks. At the dosing schedule and concentrations tested, CAW did not improve behavioral performance, EAE motor disability, or degrees of demyelination. However, CAW-treated mice demonstrated increases in nuclear factor (erythroid-derived 2)-like 2 and other antioxidant response element genes, and increases in mitochondrial respiratory activity. Caw also decreased spinal cord inflammation. Our findings indicate that CAW can increase antioxidant gene expression and mitochondrial respiratory activity in mice with EAE, supporting investigation of the clinical effects of CAW in people with MS.

Keywords

Centella asiatica; Antioxidant; Experimental autoimmune encephalomyelitis; Mitochondrial respiration

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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