Chen, Y.; Hu, C.; Wang, Z.; Su, J.; Wang, S.; Li, B.; Liu, X.; Yuan, Z.; Li, D.; Wang, H.; Zhu, B.; Shao, Y. Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort. Pathogens2023, 12, 1254.
Chen, Y.; Hu, C.; Wang, Z.; Su, J.; Wang, S.; Li, B.; Liu, X.; Yuan, Z.; Li, D.; Wang, H.; Zhu, B.; Shao, Y. Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort. Pathogens 2023, 12, 1254.
Chen, Y.; Hu, C.; Wang, Z.; Su, J.; Wang, S.; Li, B.; Liu, X.; Yuan, Z.; Li, D.; Wang, H.; Zhu, B.; Shao, Y. Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort. Pathogens2023, 12, 1254.
Chen, Y.; Hu, C.; Wang, Z.; Su, J.; Wang, S.; Li, B.; Liu, X.; Yuan, Z.; Li, D.; Wang, H.; Zhu, B.; Shao, Y. Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort. Pathogens 2023, 12, 1254.
Abstract
Vaccination has proven highly effective against severe acute res-piratory syndrome coronavirus 2 (SARS-CoV-2), but the long-term immunogenicity and the functional preserved im-mune responses of vaccines are needed to inform evolving evi-dence-based guidelines for boosting schedules. We enrolled 205 healthcare workers into a cohort study; all had received three doses of BBIBP-CorV (China Sinopharm Bio-Beijing Company) inactivated vaccine. We assessed SARS-CoV-2 specific binding antibodies, neutralizing antibody, and peripheral T and B cell responses. We demonstrated that more robust antibody re-sponses to SARS-CoV-2 were elicited by booster immunization compared to primary vaccination. Neutralizing antibody titers to SARS-CoV-2 Omicron variant were also efficiently elevated post homologous vaccine booster despite in a lower titer compared to the prototype stain. In addition to S specific humoral and cellular immunity, BBIBP-CorV also induced N-specific antibody and ef-fector T cell responses. The third-dose vaccination led to further expansion of critical polyfunctional T cell responses, likely an essential element for vaccine protection. In particular, a func-tional role for Tfh cell subsets in immunity was suggested by the correlation between both CD4+Tfh and CD8+Tfh with total anti-body, IgG, B cell responses and neutralizing antibodies. Our study details the humoral and cellular responses generated by the BBIBP-CorV booster vaccination in a seven-month follow up study. There is a clear immunologic boosting value of homolo-gous inactivated SARS-CoV-2 vaccine boosters, a consideration for future vaccine strategies.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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