Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Sepsis Outcome after Major Abdominal Surgery Does Not Seem to Be Improved by the Use of Pentameric Immunoglobulin IgM

Version 1 : Received: 18 August 2023 / Approved: 31 August 2023 / Online: 31 August 2023 (10:40:08 CEST)

A peer-reviewed article of this Preprint also exists.

Perrella, A.; Rinaldi, L.; Guarino, I.; Bernardi, F.F.; Castriconi, M.; Antropoli, C.; Pafundi, P.C.; Di Micco, P.; Sarno, M.; Capoluongo, N.; Minei, G.; Perrella, M.; Frangiosa, A.; Capuano, A. Sepsis Outcome after Major Abdominal Surgery Does Not Seem to Be Improved by the Use of Pentameric Immunoglobulin IgM: A Single-Center Retrospective Analysis. J. Clin. Med. 2023, 12, 6887. Perrella, A.; Rinaldi, L.; Guarino, I.; Bernardi, F.F.; Castriconi, M.; Antropoli, C.; Pafundi, P.C.; Di Micco, P.; Sarno, M.; Capoluongo, N.; Minei, G.; Perrella, M.; Frangiosa, A.; Capuano, A. Sepsis Outcome after Major Abdominal Surgery Does Not Seem to Be Improved by the Use of Pentameric Immunoglobulin IgM: A Single-Center Retrospective Analysis. J. Clin. Med. 2023, 12, 6887.

Abstract

Background: Sepsis still represents a major public health issue worldwide, and immune system plays a main role during infections and therefore its activity is mandatory to resolve this clinical condition In this report we aimed to retrospectively verify in real life setting the possible usefulness of Pentameric IgM plus antibiotic in recovering patients with sepsis after major abdominal surgery Materials/methods: We reviewed, from January 2013 until December 2018, all adult patients admitted in ICU for Sepsis or Septic shock (2) after major abdominal surgery. Among these patients, were identified those that according to legal indication and licence in Italy, were treated with Pentameric IgM plus antibiotic (Group A) or with antibiotic alone (Group B). We analysed the following parameters were evaluated: Blood gas analysis, Lactate, CRP, Procalcitonin, Endotoxin activity, Liver and Renal Function, Coagulation, Blood Cell count at different time points (Every 48 hrs for at least 7 days. Differences between groups have been analysed by Fisher’s exact test or Chi square test for categorical variables. Mann–Whitney U test or Kruskal–Wallis test have instead been performed to compare continuous variables. Univariate and Multivariate analysis were also performed Results: Over a period of 30 months 24 patients were enrolled in Group A and 20 patients in Group B. In those subjects no statistical differences have been found in terms of bacterial or fungal infection isolates, when detected in a blood culture test, or in inflammatory index, SOFA score, lactate levels and mortality rate. A 48hrs response was statistically more frequent in Group B than in Group A, while no differences were found in the other clinical and laboratory evaluation. Conclusions: Based on our results, the use of pentameric IgM do not seem to give any clinical advantage in sepsis after to major abdominal surgery.

Keywords

Pentaglobin; Sepsis; Infectionm Abdominal infection

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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