Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus

Umme Laila Urmi; Samuel Attard; Ajay Kumar Vijay; Mark D. P. Willcox; Naresh Kumar; Salequl Islam; Rajesh Kuppusamy

doi:10.20944/preprints202308.2017.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202308.2017.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus

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Version 1 : Received: 28 August 2023 / Approved: 28 August 2023 / Online: 30 August 2023 (07:21:19 CEST)

A peer-reviewed article of this Preprint also exists.

Urmi, U.L.; Attard, S.; Vijay, A.K.; Willcox, M.D.P.; Kumar, N.; Islam, S.; Kuppusamy, R. Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus. Antibiotics 2023, 12, 1436. Urmi, U.L.; Attard, S.; Vijay, A.K.; Willcox, M.D.P.; Kumar, N.; Islam, S.; Kuppusamy, R. Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus. Antibiotics 2023, 12, 1436.

Abstract

The development of potent antiviral agents is of utmost importance to combat the global burden of viral infections. Traditional antiviral drug development involves targeting specific viral proteins, which may lead to the emergence of resistant strains. To explore alternative strategies, we investigated the antiviral potential of antimicrobial peptidomimetic compounds. In this study, we evaluated the antiviral potential of short anthranilamide-based peptidomimetic compounds 1-17 against two viruses: Murine Hepatitis Virus 1 (MHV-1-single stranded RNA virus) which is a surrogate of human coronaviruses and Herpes Simplex Virus 1 (HSV-1-double stranded DNA virus). The half-maximal inhibitory concentration (IC50) values of these compounds were determined in vitro to assess their potency as antiviral agents. Compounds 11 and 14 displayed the most potent inhibitory effect with IC50 values of 2.38μM, and 6.3μM against MHV-1 while compounds 9 and 14 showed IC50 values of 14.8μM and 13μM, against HSV-1. Multiple antiviral assessments and microscopic images obtained through transmission electron microscopy (TEM) collectively demonstrated that these compounds exert a direct influence on the viral envelope. Based on this outcome, it can be concluded that peptidomimetic compounds could offer a new approach for the development of potent antiviral agents.

Keywords

antiviral compounds; peptidomimetics; MHV-1; HSV-1; envelope disruption

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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