Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chat GPT in Diagnostic Human Pathology: Will It Really Be Useful to the Pathologist?

Version 1 : Received: 25 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (13:15:21 CEST)

How to cite: Cazzato, G.; Capuzzolo, M.; Parente, P.; Arezzo, F.; Loizzi, V.; Marzullo, A.; Cormio, G.; Ingravallo, G. Chat GPT in Diagnostic Human Pathology: Will It Really Be Useful to the Pathologist?. Preprints 2023, 2023081990. https://doi.org/10.20944/preprints202308.1990.v1 Cazzato, G.; Capuzzolo, M.; Parente, P.; Arezzo, F.; Loizzi, V.; Marzullo, A.; Cormio, G.; Ingravallo, G. Chat GPT in Diagnostic Human Pathology: Will It Really Be Useful to the Pathologist?. Preprints 2023, 2023081990. https://doi.org/10.20944/preprints202308.1990.v1

Abstract

Abstract: The advent of Artificial Intelligence (AI) has in just a few years invested multiple areas of knowledge, also affecting the medical-scientific sector. An increasing number of AI-based applications have been developed, among which conversational AI has emerged. Among these, ChatGPT has risen to the headlines, scientific and otherwise, for its distinct propensity to simulate a 'real' discussion with its interlocutor, based on appropriate prompts. Although several clinical studies using ChatGPT have already been published in the literature, very little has yet been written about its potential application in human pathology. We conduct a systematic review following the Preferred Reporting Items for Systematic Re-views and Meta-Analyses (PRISMA) guidelines, using PubMed and Scopus as databases, with the fol-lowing keywords: ChatGPT OR Chat GPT, in combination with each of the following: Pathology, di-ag-nostic pathology, anatomic pathology. A total of 90 records were initially identified in the literature search, of which 6 were duplicates. After screening for eligibility and inclusion criteria, only 5 publications were ultimately included. The majority of publications were original articles (n = 2), followed by case reports (n = 1), letter to the editor (n = 1) and review (n = 1). Although the premises are exciting and ChatGPT is able to co-advise the pathologist in providing large amounts of scientific data for use in routine microscopic diagnostic practice, there are many limitations that need to be addressed and resolved, with the caveat that an AI-driven system should always provide support and never a decision-making motive during the anatomo-pathological diagnostic process.

Keywords

ChatGPT; chatbot; Artificial Intelligence; AI; Pathology; Histology

Subject

Medicine and Pharmacology, Pathology and Pathobiology

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