The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Vasileios Georgoulis; Epameinondas Koumpis; Eleftheria Hatzimichael

doi:10.20944/preprints202308.1982.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 28 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (13:42:14 CEST)

Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia and an increased risk for evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review will present a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

myelodysplastic syndromes; non-coding RNA; microRNA; lnc-RNA; circ-RNA; piwi-RNA; t-RNA; sno-RNA

Medicine and Pharmacology, Hematology

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The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

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