Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Effects of Diabetes and Being Overweight on Patients with Post-COVID-19 Syndrome

Version 1 : Received: 26 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (03:18:29 CEST)

How to cite: Kirbiš, S.; Sobotkiewicz, N.; Schaubach, B.A.; Završnik, J.; Kokol, P.; Završnik, M.; Blažun Vošner, H. The Effects of Diabetes and Being Overweight on Patients with Post-COVID-19 Syndrome. Preprints 2023, 2023081915. https://doi.org/10.20944/preprints202308.1915.v1 Kirbiš, S.; Sobotkiewicz, N.; Schaubach, B.A.; Završnik, J.; Kokol, P.; Završnik, M.; Blažun Vošner, H. The Effects of Diabetes and Being Overweight on Patients with Post-COVID-19 Syndrome. Preprints 2023, 2023081915. https://doi.org/10.20944/preprints202308.1915.v1

Abstract

In the aftermath of the COVID pandemic, post-COVID-19 syndrome (PCS) remains a challenge and may continue to represent a major health problem in the future. Moreover, the influence of type 2 diabetes and being overweight on PCS remains unclear. This study aimed to assess this influence. We performed an observational study from October 2020 to July 2022, which included 466 patients (269 males and 197 females) with a median age of 65. They were hospitalized due to COVID-19 pneumonia and had persistent symptoms after 1 month of COVID-19 infection. The patients were divided into four groups according to the study objectives: patients with type 2 diabetes, overweight patients, overweight patients with type 2 diabetes, and normal-weight patients without type 2 diabetes. The clinical and demographic data collected during hospitalization and regular visits at the Community Healthcare Center dr. Adolf Drolc Maribor were analyzed. Our results showed that type 2 diabetes patients had a more difficult course of treatment and longer hospitalization. Moreover, more type 2 diabetes patients underwent rehabilitation than the other study groups. The prevailing symptoms in our patients with PCS were dyspnea and fatigue, mostly in female patients with type 2 diabetes. Our study also showed that more women with type 2 diabetes and more overweight women with type 2 diabetes suffered from secondary infections. Further, more overweight patients were treated in the intensive care unit compared to the other groups. However, our study showed an interesting result that patients with type 2 diabetes had the shortest PCS durations. Type 2 diabetes and being overweight are risk factors for PCS onset and prolonged duration. Therefore, our data that revealed a shorter duration of PCS in type 2 diabetes patients compared to the other investigated groups was unexpected. We believe that answering this question regarding the results will enable us to improve PCS treatment in general.

Keywords

post-COVID-19 syndrome; diabetes; overweight; COVID-19 pneumonia; observational study

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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