Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphomae

Georgina Almaguer
ORCID logo ,
Gustavo Almaguer-Vargas
* ,
Eva Maria Molina
,
Marco Antonio Becerril
,
Brenda Montejano
,
Eduardo Osiris Madrigal
ORCID logo ,
Alejandra Hernandez
,
Ana Hilda Figueroa
,
Ethoan Montejano
,
José Ramón Montejano
*
Version 1 : Received: 25 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (09:29:07 CEST)

A peer-reviewed article of this Preprint also exists.

Almaguer, G.; Almaguer-Vargas, G.; Molina-Trinidad, E.M.; Becerril-Flores, M.A.; Montejano, B.; Madrigal-Santillan, E.; Hernández-Ceruelos, A.; Figueroa-Gutiérrez, A.H.; Montejano, E.; Montejano-Rodríguez, J.R. Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphoma. Plants 2023, 12, 3757. Almaguer, G.; Almaguer-Vargas, G.; Molina-Trinidad, E.M.; Becerril-Flores, M.A.; Montejano, B.; Madrigal-Santillan, E.; Hernández-Ceruelos, A.; Figueroa-Gutiérrez, A.H.; Montejano, E.; Montejano-Rodríguez, J.R. Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphoma. Plants 2023, 12, 3757.

Abstract

The search for more efficacy and fewer toxic effects in cancer treatments is the main objective of research into new therapies. Vincristine (VCR) is a chemotherapeutic used in different types of tumors. Epigallocatechin gallate (EGCG) is a green tea metabolite that has shown an antineoplastic effect in different investigations, so the objective of this work was to evaluate the antitumor effect of the EGCG/VCR combination on tumor volume and survival. To achieve this objective, the solid model of lymphoma L5178Y was used in BALB/c mice with different doses of VCR, EGCG and their combination; Tumor grow and survival time were recorded. Once the tumors were obtained, they were measured and immunohistochemistry was performed for p53, Bcl2 and CD1. The results showed that the EGCG/vincristine combination had a greater antitumor effect that vincristine and EGCG. This can be partly attributed to the fact that the greatest Bcl2 inhibition was present in the combination of EGCG with vincristine. Therefore, it can be concluded that the combination of EGCG with vincristine has a better antineoplastic effect by inhibiting tumor development and increasing survival than both substances independently.

Keywords

EGCG; Cancer; Vincristine; p53; Bcl2

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.