Version 1
: Received: 28 August 2023 / Approved: 28 August 2023 / Online: 29 August 2023 (03:45:30 CEST)
How to cite:
Sissons, C.; Saeed, F.; Carter, C.; Lee, K.; Kerr, K.; Shahdadian, S.; Liu, H. Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults. Preprints2023, 2023081869. https://doi.org/10.20944/preprints202308.1869.v1
Sissons, C.; Saeed, F.; Carter, C.; Lee, K.; Kerr, K.; Shahdadian, S.; Liu, H. Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults. Preprints 2023, 2023081869. https://doi.org/10.20944/preprints202308.1869.v1
Sissons, C.; Saeed, F.; Carter, C.; Lee, K.; Kerr, K.; Shahdadian, S.; Liu, H. Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults. Preprints2023, 2023081869. https://doi.org/10.20944/preprints202308.1869.v1
APA Style
Sissons, C., Saeed, F., Carter, C., Lee, K., Kerr, K., Shahdadian, S., & Liu, H. (2023). Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults. Preprints. https://doi.org/10.20944/preprints202308.1869.v1
Chicago/Turabian Style
Sissons, C., Sadra Shahdadian and Hanli Liu. 2023 "Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults" Preprints. https://doi.org/10.20944/preprints202308.1869.v1
Abstract
A recent study demonstrated that noninvasive measurements of cortical hemodynamics and metabolism in the resting human prefrontal cortex can facilitate quantitative metrics of unilateral mitochondrial-hemodynamic coupling and bilateral connectivity in infraslow oscillation (ISO) frequencies in young adults (YA). The ISO includes three distinct vasomotions with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. The goal of this study was to prove the hypothesis that there are significant differences between young and older adults (OA) in the unilateral coupling (uCOP) and bilateral connectivity (bCON) in the prefrontal cortex. Accordingly, we performed measurements from 24 OA (67.2 ± 5.9 years of age) using the same 2-channel broadband near-infrared spectroscopy (bbNIRS) setup and resting-state experimental protocol as those in the recent study (Shahdadian et al, Cerebral Cortex Communications, 2022). After quantification of uCOP and bCON in three E/N/M frequencies and statistical analysis, we demonstrated that OA had significantly weaker bilateral hemodynamic connectivity but significantly stronger bilateral metabolic connectivity than YA in the M band. Furthermore, OA exhibited significantly stronger unilateral coupling on both prefrontal sides in all E/N/M bands, particularly with a very large effect size in the M band (> 1.9). These age-related results clearly support our hypothesis and were well interpreted following neurophysiological principles. The key finding of this paper is that the neurophysiological metrics of uCOP and bCON are highly associated with age and may have the potential to become meaningful features for human brain health and be translatable for future clinical applications, such as early detection of Alzheimer’s disease.
Keywords
Age difference in prefrontal cortex; mitochondrial and hemodynamic coupling; prefrontal cortical connectivity; resting state functional connectivity; broadband near-infrared spectroscopy
Subject
Engineering, Bioengineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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