Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

6-Lead Electrocardiography is a Viable Option for Identification of Rhythm and Conduction Anomalies of Patients in the Telemedicine-Based, Hospital-at-Home Setting. A Prospective Validation Study

Version 1 : Received: 23 August 2023 / Approved: 24 August 2023 / Online: 28 August 2023 (10:26:47 CEST)

A peer-reviewed article of this Preprint also exists.

Sharabi, A.; Abutbul, E.; Grossbard, E.; Martsiano, Y.; Berman, A.; Kassif-Lerner, R.; Hakim, H.; Liber, P.; Zoubi, A.; Barkai, G.; Segal, G. Six-Lead Electrocardiography Enables Identification of Rhythm and Conduction Anomalies of Patients in the Telemedicine-Based, Hospital-at-Home Setting: A Prospective Validation Study. Sensors 2023, 23, 8464. Sharabi, A.; Abutbul, E.; Grossbard, E.; Martsiano, Y.; Berman, A.; Kassif-Lerner, R.; Hakim, H.; Liber, P.; Zoubi, A.; Barkai, G.; Segal, G. Six-Lead Electrocardiography Enables Identification of Rhythm and Conduction Anomalies of Patients in the Telemedicine-Based, Hospital-at-Home Setting: A Prospective Validation Study. Sensors 2023, 23, 8464.

Abstract

Abstract: Background: The Hospital-at-home (HAH) model is a viable alternative for conven-tional in-hospital stays worldwide. Serum electrolyte abnormalities are common in acute pa-tients, especially in those with many comorbidities. Pathologic changes in cardiac electrophysi-ology pose a potential risk during HAH stay. Periodical Electrocardiogram (ECG) tracing is therefore advised, but few studies evaluated the accuracy and efficiency of compact, self-activated ECG devices in the HAH settings. This study aimed to evaluate the reliability of such a device in comparison to a standard 12-lead ECG. Methods: We prospectively recruited consecu-tive patients admitted to the Sheba Beyond, virtual hospital, in the HAH department, during a 3-month duration. Each patient underwent a 12-lead ECG recording using the legacy device, and a consecutive recording by a compact 6-lead device. Baseline patients’ characteristics during hospi-talization were collected. Level of agreement between devices was measured by Cohen’s Kappa coefficient for inter-rater reliability (Ϗ). Results: Fifty patients were included in the study. 26 (52%) had electrolyte disturbances. Abnormal D-dimer values were observed in 33 (66%) pa-tients, and 12 (24%) patients had elevated troponin values. We found a level of 94.5% raw agreement between devices with regards to nine of the options included in the automatic read-out of the legacy device. The calculated Ϗ was 0.72, classified as substantial consensus. The rate of raw consensus regarding ECG intervals’ measurement (PR, RR, QT) was 78.5% and the calculated Ϗ was 0.42, corresponding to a moderate level of agreement. Conclusion: This is the first report to our knowledge regarding the feasibility of using a compact, 6-Lead ECG device in the setting of HAH to be safe and bearing satisfying agreement level with a legacy, 12-lead ECG device, en-abling quick, accessible arrythmia detection in this setting. Our findings bear a promise to the future development of telemedicine-based hospital at home methodology.

Keywords

Electrocardiography; Hospital at home; Arrythmia; ECG Intervals; Electrolyte disturbances; 6 Lead ECG

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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