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Version 1
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Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks
Version 1
: Received: 22 August 2023 / Approved: 23 August 2023 / Online: 23 August 2023 (07:17:32 CEST)
A peer-reviewed article of this Preprint also exists.
Kerch, G. Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks. Gels 2023, 9, 754. Kerch, G. Nanocomposite Hydrogels and Extracellular Matrix—Advantages and Associated Risks. Gels 2023, 9, 754.
Abstract
Hydrogels can be considered as mimics of extracellular matrix (ECM).Cytoskeleton through integrins is connected with ECM and cytoskeleton tension depends on ECM stiffness.A number of age-related diseases depend on cellular processes related with cytoskeleton function.Some examples of cancer initiation and progression and heart disease in relationship with ECM stiffness has been analysed.Incorporation of rigid particles in ECM can increase ECM stifness and to promote formation of internal residual stresses. Water migration, changes of water binding energy to biomactomolecules, changes of the state of water from tightly bound water to free and loosely bound water changes stiffness of ECM. Risks related with rigid particles incorporation into ECM have been also iscussed.
Keywords
Hydrogel; Extracellular matrix; Stiffness; Cell; Cancer; Internal stresses; Bound water
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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