Version 1
: Received: 22 August 2023 / Approved: 22 August 2023 / Online: 23 August 2023 (09:18:30 CEST)
How to cite:
Papanikolaou, A.; Anastasiou, G.; Barkas, F.; Tellis, C.; Zikopoulos, K.; Liberopoulos, E. Association of Serum Estradiol with PCSK9 Levels and Lipid Profile in Women Undergoing In Vitro Fertilization. Preprints2023, 2023081602. https://doi.org/10.20944/preprints202308.1602.v1
Papanikolaou, A.; Anastasiou, G.; Barkas, F.; Tellis, C.; Zikopoulos, K.; Liberopoulos, E. Association of Serum Estradiol with PCSK9 Levels and Lipid Profile in Women Undergoing In Vitro Fertilization. Preprints 2023, 2023081602. https://doi.org/10.20944/preprints202308.1602.v1
Papanikolaou, A.; Anastasiou, G.; Barkas, F.; Tellis, C.; Zikopoulos, K.; Liberopoulos, E. Association of Serum Estradiol with PCSK9 Levels and Lipid Profile in Women Undergoing In Vitro Fertilization. Preprints2023, 2023081602. https://doi.org/10.20944/preprints202308.1602.v1
APA Style
Papanikolaou, A., Anastasiou, G., Barkas, F., Tellis, C., Zikopoulos, K., & Liberopoulos, E. (2023). Association of Serum Estradiol with PCSK9 Levels and Lipid Profile in Women Undergoing In Vitro Fertilization. Preprints. https://doi.org/10.20944/preprints202308.1602.v1
Chicago/Turabian Style
Papanikolaou, A., Konstantinos Zikopoulos and Evangelos Liberopoulos. 2023 "Association of Serum Estradiol with PCSK9 Levels and Lipid Profile in Women Undergoing In Vitro Fertilization" Preprints. https://doi.org/10.20944/preprints202308.1602.v1
Abstract
Background: The mechanisms underlying the effect of estradiol (E2) on low-density lipoprotein cholesterol (LDL-C) levels are not completely understood, although a role for proprotein con-vertase subtilisin/kexin type 9 (PCSK9) has been proposed. We aimed to investigate the association between levels of E2, PCSK9 and lipid parameters in premenopausal women undergoing in vitro fertilization (IVF). Methods: Healthy women undergoing IVF in the Department of Obstetrics and Gynecology of the University General Hospital of Ioannina were recruited. Levels of E2, pro-protein convertase subtilisin/kexin type 9 (PCSK9), total cholesterol (TCHOL), high-density lip-oprotein cholesterol (HDL-C), LDL-C, and triglycerides (TGs) were measured 10 days after ovarian depression (E2min) and 7 days after ovarian stimulation (E2max). Results: A total of 34 consecutive healthy women aged 38 (26-46) years old who underwent a full IVF cycle were included. E2 levels increased by 329.6% from E2min to E2max (108 [47-346] to 464 [241-2471] pg/mL, p<0.05). At the same time, serum PCSK9 levels significantly decreased by 30.8% (245 ± 80 to 170 ± 64 ng/mL, p<0.05). No significant changes in TCHOL, LDL-C, TGs and HDL-C were found (-0.4%, -3.8%, -2.2%, and +5.3%, p >0.05). Conclusions: The increase in endogenous E2 production during an IVF cycle was associated with a significant decrease in serum PCSK9 levels during a 7-day period.
Keywords
estrogens; proprotein convertase subtilisin/kexin type 9; lipoprotein; low-density lipoprotein cholesterol; cholesterol; lipids; in vitro fertilization
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
*
