Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Are Bronchiectasis (BE) Properly Investigated in Patients with Severe Asthma? A Real-Life Report from 8 Italian Centers

Giovana Elisiana Carpagnano
,
Vitaliano Nicola Quaranta
* ORCID logo ,
Claudia Crimi
ORCID logo ,
Pierachille Santus
ORCID logo ,
Francesco Menzella
,
Corrado Pelaia
ORCID logo ,
Giulia Scioscia
,
Cristiano Caruso
ORCID logo ,
Elena Bargagli
ORCID logo ,
Nicola Scichilone
ORCID logo ,
Eva Polverino
Version 1 : Received: 18 August 2023 / Approved: 22 August 2023 / Online: 22 August 2023 (08:02:00 CEST)

A peer-reviewed article of this Preprint also exists.

Carpagnano, G.E.; Quaranta, V.N.; Crimi, C.; Santus, P.; Menzella, F.; Pelaia, C.; Scioscia, G.; Caruso, C.; Bargagli, E.; Scichilone, N.; Polverino, E. Is Bronchiectasis (BE) Properly Investigated in Patients with Severe Asthma? A Real-Life Report from Eight Italian Centers. J. Respir. 2023, 3, 178-190. Carpagnano, G.E.; Quaranta, V.N.; Crimi, C.; Santus, P.; Menzella, F.; Pelaia, C.; Scioscia, G.; Caruso, C.; Bargagli, E.; Scichilone, N.; Polverino, E. Is Bronchiectasis (BE) Properly Investigated in Patients with Severe Asthma? A Real-Life Report from Eight Italian Centers. J. Respir. 2023, 3, 178-190.

Abstract

Introduction: Asthma and bronchiectasis are often partners in a complex but uneven relationship with asthma receiving more attentions. The aim of this study is to describe how bronchiectasis are investigated in some Severe Asthma (SA) Centers scattered throughout the Italian territory. Materials and Methods: We enrolled 92 patients with SA and bronchiectasis from 8 Italian SA Centers and recorded diagnostic approaches to investigate SA and bronchiectasis at the time of enrollment (T0), at the 6-month (T1), and at the 12- month (T2) follow-up visits. Results: A statistically significant heterogeneous diagnostic approach emerged across the centers under study In fact, while, as expected, all involved centers made an in-depth investigation of SA, only few of them made a complete investigation of bronchiectasis in order to provide specific treatment. Discussion: This real-life multicenter study confirmed that patients with coexistent SA and bronchiectasis are mainly investigated for pheno-endotyping asthma but rarely for complete assessment of bronchiectasis. We believe that the diagnostic flowchart of SA patients with suspicion or confirmed bronchiectasis needs to be clarified and implemented as the association of these conditions strongly influences final outcomes and management of these patients.

Keywords

asthma; bronchiectasis; severe asthma

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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