Alfinito, E. TBA for Sensing Toxic Cations: A Critical Analysis of Structural and Electrical Properties. Int. J. Mol. Sci.2023, 24, 14492.
Alfinito, E. TBA for Sensing Toxic Cations: A Critical Analysis of Structural and Electrical Properties. Int. J. Mol. Sci. 2023, 24, 14492.
Alfinito, E. TBA for Sensing Toxic Cations: A Critical Analysis of Structural and Electrical Properties. Int. J. Mol. Sci.2023, 24, 14492.
Alfinito, E. TBA for Sensing Toxic Cations: A Critical Analysis of Structural and Electrical Properties. Int. J. Mol. Sci. 2023, 24, 14492.
Abstract
Food and drinks can be contaminated with pollutants such as lead and strontium and this poses a serious danger to human health. For this reason, a number of effective sensors have been developed for the rapid and highly selective detection of such contaminants. TBA, a well-known aptamer developed to selectively target and thereby inhibit the protein of clinical interest -thrombin, is receiving increasing attention for sensing applications, particularly for the sensing of different cations. Indeed, TBA, in the presence of these cations, folds into the stable G-quadruplex structure. Furthermore, different cations produce small but significant changes in this structure that result in changes in the electrical responses that TBA can produce. In this article we produce an overview of the expected data regarding the use of TBA in the detection of lead and strontium, calculating the expected electrical response using different measurement techniques. Finally, we conclude that the TBA should perform better as a detector of strontium rather than lead.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
