Tsuji, K.; Nakanoh, H.; Fukushima, K.; Kitamura, S.; Wada, J. MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury. Diagnostics2023, 13, 2893.
Tsuji, K.; Nakanoh, H.; Fukushima, K.; Kitamura, S.; Wada, J. MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury. Diagnostics 2023, 13, 2893.
Tsuji, K.; Nakanoh, H.; Fukushima, K.; Kitamura, S.; Wada, J. MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury. Diagnostics2023, 13, 2893.
Tsuji, K.; Nakanoh, H.; Fukushima, K.; Kitamura, S.; Wada, J. MicroRNAs as Biomarkers and Therapeutic Targets for Acute Kidney Injury. Diagnostics 2023, 13, 2893.
Abstract
Acute kidney injury (AKI) is a clinical syndrome where a rapid decrease in kidney function and/or urine output is observed, which may result in the imbalance of water, electrolyte and acid base, and is associated with poor prognosis and prolonged hospitalization. Therefore, early diagnosis and treatment to avoid the severe AKI stage is important. While several biomarkers, such as urinary L-FABP and NGAL, can be clinically useful, there is still no gold standard for early detection of AKI and there are limited therapeutic options against AKI. miRNAs are non-coding and single-stranded RNAs that silence their target genes in the post-transcriptional process and are involved in a wide range of biological processes. Recent accumulated evidence has revealed that miRNAs may be potential biomarkers and therapeutic targets for AKI. In this review article, we summarize the current knowledge about miRNAs as promising biomarkers and potential therapeutic targets for AKI, as well as the challenges in their clinical use.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
