Howes, L.G.; Unni, T.; Hamza, A.; Howes, J.B.; Jayasinghe, R. Reduction in Arterial Stiffness Index (SI) in Response to Combination Antioxidant Therapy. J. Clin. Med.2023, 12, 6804.
Howes, L.G.; Unni, T.; Hamza, A.; Howes, J.B.; Jayasinghe, R. Reduction in Arterial Stiffness Index (SI) in Response to Combination Antioxidant Therapy. J. Clin. Med. 2023, 12, 6804.
Howes, L.G.; Unni, T.; Hamza, A.; Howes, J.B.; Jayasinghe, R. Reduction in Arterial Stiffness Index (SI) in Response to Combination Antioxidant Therapy. J. Clin. Med.2023, 12, 6804.
Howes, L.G.; Unni, T.; Hamza, A.; Howes, J.B.; Jayasinghe, R. Reduction in Arterial Stiffness Index (SI) in Response to Combination Antioxidant Therapy. J. Clin. Med. 2023, 12, 6804.
Abstract
Antioxidants reduce arterial stiffness but the effects previously reported are weak. The present study evaluated the effects of 2 weeks of therapy with a combination of antioxidants (l-cysteine, thiamine, pyridoxine and ascorbic acid) compared to placebo on stiffness index (SI) a measure of arterial stiffness that is strongly correlated with central pulse wave velocity (PWV), using a Pulse Trace recorder in a diverse group of 78 volunteers. SI fell by 1.7 m/sec relative to placebo (95% confidence intervals 0.6 to 2.7 m/sec), a reduction of 19% (95% confidence intervals 9% to 31%). The Glass effect size was 1.4, indicating a very strong treatment effect which was substantially greater than found in previous studies of the effects of antioxidant therapy on arterial stiffness. The magnitude of reduction in SI was positively correlated with increasing age (r = 0.362 P = 0.02). The change in RI, a measure of compliance of small to medium size arteries, did not differ between the antioxidant and placebo groups The combination of antioxidants studied reduced PWV to a much greater extent than reported for other antioxidants. This combination may be of value in the treatment of cardiovascular disease.
Keywords
Antioxidants; arterial stiffness; pulse wave velocity; stiffness index
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
