Article
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Selective Impact of Selenium Compounds on Two Cytokine Storm Players
Version 1
: Received: 14 August 2023 / Approved: 15 August 2023 / Online: 16 August 2023 (08:06:28 CEST)
A peer-reviewed article of this Preprint also exists.
Sinha, I.; Zhu, J.; Sinha, R. Selective Impact of Selenium Compounds on Two Cytokine Storm Players. J. Pers. Med. 2023, 13, 1455. Sinha, I.; Zhu, J.; Sinha, R. Selective Impact of Selenium Compounds on Two Cytokine Storm Players. J. Pers. Med. 2023, 13, 1455.
Abstract
COVID-19 patients suffer from detrimental effects of cytokine storm and not much success has been achieved to overcome this issue. We sought to test the ability of selenium in reducing the impact of two important cytokine storm players; IL-6 and TNF-a. The effects of four selenium compounds were evaluated on the secretion of these cytokines from THP-1 macrophages in vitro following LPS challenge. Also, potential impact of methylseleninic acid (MSeA) on Nrf2 and IkBa was determined following short treatment of THP-1 macrophages. MSeA was observed to be the most potent selenium form to reduce IL-6 and TNF-a levels among the four selenium compounds tested. In addition, an increase in Nrf2 and decrease in pIkBa in human macrophages was observed following MSeA treatment. Our data indicate that COVID-19 patients might benefit by suppressing their cytokine storm with addition of MSeA to the standard therapy.
Keywords
methylseleninic acid; sodium selenite; selenous acid; selenomethionine, cytokines, cytokine storm; COVID-19
Subject
Biology and Life Sciences, Other
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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