Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges

Jaqueline Costa Leite
,
Ana Alice Maia Gonçalves
ORCID logo ,
Diana Souza De Oliveira
,
Lucilene Aparecida Resende
,
Diego Fernandes Vilas Boas
,
Helen Silva Ribeiro
ORCID logo ,
Diogo Fonseca Soares Pereira
,
Augusto Ventura Da Silva
,
Reysla Maria da Silveira Mariano
,
Pedro Campos Carvalhaes Reis
,
Eiji Nakasone Nakasone
,
João Carlos França-Silva
,
Alexsandro Sobreira Galdino
ORCID logo ,
Paulo Ricardo de Oliveira Paes
,
Marília Martins Melo
ORCID logo ,
Edelberto Santos Dias
ORCID logo ,
Miguel Angel Chávez Fumagalli
ORCID logo ,
Denise Da Silveira-Lemos
,
Walderez Ornelas Dutra
,
Rodolfo Cordeiro Giunchetti
* ORCID logo
Version 1 : Received: 11 August 2023 / Approved: 14 August 2023 / Online: 14 August 2023 (15:15:25 CEST)

A peer-reviewed article of this Preprint also exists.

Leite, J.C.; Gonçalves, A.A.M.; de Oliveira, D.S.; Resende, L.A.; Boas, D.F.V.; Ribeiro, H.S.; Pereira, D.F.S.; da Silva, A.V.; Mariano, R.M.S.; Reis, P.C.C.; Nakasone, E.N.; França-Silva, J.C.; Galdino, A.S.; Paes, P.R.O.; Melo, M.M.; Dias, E.S.; Chávez-Fumagalli, M.A.; da Silveira-Lemos, D.; Dutra, W.O.; Giunchetti, R.C. Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges. Vaccines 2023, 11, 1565. Leite, J.C.; Gonçalves, A.A.M.; de Oliveira, D.S.; Resende, L.A.; Boas, D.F.V.; Ribeiro, H.S.; Pereira, D.F.S.; da Silva, A.V.; Mariano, R.M.S.; Reis, P.C.C.; Nakasone, E.N.; França-Silva, J.C.; Galdino, A.S.; Paes, P.R.O.; Melo, M.M.; Dias, E.S.; Chávez-Fumagalli, M.A.; da Silveira-Lemos, D.; Dutra, W.O.; Giunchetti, R.C. Transmission-Blocking Vaccines for Canine Visceral Leishmaniasis: New Progress and Yet New Challenges. Vaccines 2023, 11, 1565.

Abstract

The dogs with canine visceral leishmaniasis (CVL) play a key role in the transmission cycle of Leishmania infantum to humans in the urban environment. There is a consensus regarding the importance of developing a vaccine to control this disease. Despite many efforts to develop a protective vaccine against CVL, the ones currently available, CaniLeish®, Leish-tec® and LetiFend® have limited effectiveness. This is due, in part, to the complexity of the immune response of the naturally infected dogs against the parasite and the complexity of the parasite transmission cycle. Thus, strategies such as the development of a transmission-blocking vaccines (TBVs), already being applied to other vector-borne diseases like malaria and dengue, would be an attractive alternative to control leishmaniasis. TBVs induce the production of antibodies in the vertebrate host, which can inhibit parasite development in the vector and/or interfere with aspects of vector biology, leading to an interruption of parasite transmission. To date, there are few TBVs studies for CVL and other leishmaniasis forms. However, the few studies that exist show promising results justifying further development of this approach.

Keywords

Canine visceral leishmaniasis, vaccines, transmission-blocking vaccines.

Subject

Biology and Life Sciences, Parasitology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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