Review
Version 2
Preserved in Portico This version is not peer-reviewed
Connecting Cryptococcal Meningitis and Gut Microbiome
Version 1
: Received: 9 August 2023 / Approved: 10 August 2023 / Online: 10 August 2023 (11:08:24 CEST)
Version 2 : Received: 10 August 2023 / Approved: 11 August 2023 / Online: 11 August 2023 (10:14:24 CEST)
Version 2 : Received: 10 August 2023 / Approved: 11 August 2023 / Online: 11 August 2023 (10:14:24 CEST)
A peer-reviewed article of this Preprint also exists.
Ma, Y.; Yang, L.; Jiang, M.; Zhao, X.; Xue, P. Connecting Cryptococcal Meningitis and Gut Microbiome. Int. J. Mol. Sci. 2023, 24, 13515. Ma, Y.; Yang, L.; Jiang, M.; Zhao, X.; Xue, P. Connecting Cryptococcal Meningitis and Gut Microbiome. Int. J. Mol. Sci. 2023, 24, 13515.
Abstract
The pathogen Cryptococcus neoformans is a major cause of fungal meningitis in humans. As with other melanotic microorganisms associated with human diseases, the cell wall-associated melanin of C. neoformans is a major virulence factor that contributes to its ability to evade host immune responses. The levels of melanin substrate and the regulation of melanin formation could be influenced by the microbiota-gut-brain axis. Moreover, recent studies show that C. neoformans infection causes dysbiosis in the human gut microbiome. In this review, we discuss the potential association between cryptococcal meningitis and the gut microbiome. Additionally, we emphasize the promising prospects of targeting the gut microbiome as a means of diagnosing and treating this debilitating disease.
Keywords
cryptococcal meningitis; melanin; catecholamines; nutritional signals; microbiota-gut-brain axis
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Peng Xue
Commenter's Conflict of Interests: Author
Regarding the references, there should be a correction. Instead of 82 papers, there should be 81 papers included. In the previous version, the 24th paper was mistakenly left empty.
Best regards,
Peng