Version 1
: Received: 8 August 2023 / Approved: 9 August 2023 / Online: 9 August 2023 (10:50:56 CEST)
How to cite:
Gabriel, Á.M.; Galué-Parra, A.; Pereira, W.L.A.; Casseb, L.M.N.; Pedersen, K.W.; Da Silva, E.O. Windows into Canine Leishmaniasis: In Vivo Diagnosis and In Vitro Promises of Extracellular Vesicles. Preprints2023, 2023080774. https://doi.org/10.20944/preprints202308.0774.v1
Gabriel, Á.M.; Galué-Parra, A.; Pereira, W.L.A.; Casseb, L.M.N.; Pedersen, K.W.; Da Silva, E.O. Windows into Canine Leishmaniasis: In Vivo Diagnosis and In Vitro Promises of Extracellular Vesicles. Preprints 2023, 2023080774. https://doi.org/10.20944/preprints202308.0774.v1
Gabriel, Á.M.; Galué-Parra, A.; Pereira, W.L.A.; Casseb, L.M.N.; Pedersen, K.W.; Da Silva, E.O. Windows into Canine Leishmaniasis: In Vivo Diagnosis and In Vitro Promises of Extracellular Vesicles. Preprints2023, 2023080774. https://doi.org/10.20944/preprints202308.0774.v1
APA Style
Gabriel, Á.M., Galué-Parra, A., Pereira, W.L.A., Casseb, L.M.N., Pedersen, K.W., & Da Silva, E.O. (2023). Windows into Canine Leishmaniasis: In Vivo Diagnosis and In Vitro Promises of Extracellular Vesicles. Preprints. https://doi.org/10.20944/preprints202308.0774.v1
Chicago/Turabian Style
Gabriel, Á.M., Ketil Winther Pedersen and Edilene Oliveira Da Silva. 2023 "Windows into Canine Leishmaniasis: In Vivo Diagnosis and In Vitro Promises of Extracellular Vesicles" Preprints. https://doi.org/10.20944/preprints202308.0774.v1
Abstract
Leishmaniases are zoonotic vector-borne diseases caused by a wide variety of Leishmania species with complex transmission cycles involving different reservoirs, potential new hosts and vectors. Similarly, to other eukaryotes, Leishmania use released extracellular vesicles (LEVs) to play important initial interactions that are crucial to modulate the subsequent systemic immune response on the establishment of infection in humans and other important hosts like dogs. Recent studies in endemic areas of Brazil concluded that canine infections were predominantly due to L. amazonensis and not restricted to L. infantum (syn. Leishmania chagasi). Under these premises, the diagnosis of canine leishmaniasis needs to be improved, including the identification of current etiological agent, the clinical differential diagnosis and the histopathologic features. In this way, the dual aim of that study is to register collected observations for the diagnosis of natural canine infections and to insert in vitro results in the field of LEVs that still research gaps to be filled to understand the mechanisms and biological aspects involving the parasite-host interactions. Therefore, the future studies of Parasitology research for both of these fields are very important for the interventions for the prevention, control, elimination and eradication worldwide.
Keywords
canine leishmaniasis; natural zoonotic infection; clinical and histopathologic features; cell communication by secreting extracellular vesicles; lipid profiles of cultured parasites.
Subject
Biology and Life Sciences, Parasitology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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