Mitochondrial Dynamics and Insulin Secretion

Uma D. Kabra; Martin Jastroch

doi:10.20944/preprints202308.0710.v1

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preprints.org > biology and life sciences > endocrinology and metabolism > doi: 10.20944/preprints202308.0710.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mitochondrial Dynamics and Insulin Secretion

Uma D. Kabra

and

Martin Jastroch

Version 1 : Received: 7 August 2023 / Approved: 8 August 2023 / Online: 9 August 2023 (08:22:26 CEST)

A peer-reviewed article of this Preprint also exists.

Kabra, U.D.; Jastroch, M. Mitochondrial Dynamics and Insulin Secretion. Int. J. Mol. Sci. 2023, 24, 13782. Kabra, U.D.; Jastroch, M. Mitochondrial Dynamics and Insulin Secretion. Int. J. Mol. Sci. 2023, 24, 13782.

Abstract

Mitochondria are involved in the regulation of cellular energy metabolism, calcium homeostasis, and apoptosis. For mitochondrial quality control, dynamic processes, such as mitochondrial fission and fusion, are necessary to maintain shape and function. Disturbances of mitochondrial dynamics lead to dysfunctional mitochondria which contribute to the development and progression of numerous diseases, including Type 2 Diabetes (T2D). Compelling evidence put forward that mitochondrial dynamics play a significant role in the metabolism-secretion coupling of pancreatic β cells. The disruption of mitochondrial dynamics is linked with defects in energy production and increased apoptosis, ultimately impairing insulin secretion and β cell death. This review provides an overview of altered mitochondrial dynamics in pancreatic β cells using ge-netic/pharmacologic approaches, and how these affect insulin secretion.

Keywords

diabetes; mitochondrial dynamics; glucose-stimulated insulin secretion; pancreatic beta cell; fusion; fission

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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