Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Comparison of Cefazolin/Metronidazole versus Ampicillin-Sulbactam as Preoperative Antibiotics in Colorectal Surgery: Retrospective, Single-Center Cohort Study

Jae Hyoung Im
,
Dong Yeop Lee
,
Ji Hyeon Baek
,
Se-joo Lee
ORCID logo ,
Sungtaek Jung
,
Eunjung Kim
,
Dong Yoon Kang
* ORCID logo ,
Jin-Soo Lee
* ORCID logo
Version 1 : Received: 7 August 2023 / Approved: 8 August 2023 / Online: 9 August 2023 (02:59:05 CEST)

A peer-reviewed article of this Preprint also exists.

Im, J.H.; Lee, D.Y.; Baek, J.H.; Lee, S.J.; Jung, S.; Kim, E.; Kang, D.Y.; Lee, J.-S. Comparison of Cefazolin/Metronidazole to Ampicillin/Sulbactam as Preoperative Antibiotics in Colorectal Surgery: A Retrospective, Single-Center Cohort Study. Antibiotics 2023, 12, 1381. Im, J.H.; Lee, D.Y.; Baek, J.H.; Lee, S.J.; Jung, S.; Kim, E.; Kang, D.Y.; Lee, J.-S. Comparison of Cefazolin/Metronidazole to Ampicillin/Sulbactam as Preoperative Antibiotics in Colorectal Surgery: A Retrospective, Single-Center Cohort Study. Antibiotics 2023, 12, 1381.

Abstract

Aim The use of prophylactic antibiotics prior to colorectal surgery reduces surgical site infections. Cefazolin and metronidazole is a standard regimen. Ampicillin-sulbactam may be an alternative, but the data are limited. We compared the efficacy of ampicillin-sulbactam with cefazolin and metronidazole as prophylactic antibiotics. Methods Patients who underwent colorectal surgery at Inha University Hospital between 2010 and 2020 were treated prophylactically with cefazolin and metronidazole or ampicillin-sulbactam, and observed for 30 days following surgery. The primary outcome was surgical site infections. Secondary outcomes were deep/organ infections and the need for drainage. Results SSIs occurred in 2.6% (17/646) of the ampicillin-sulbactam group and was not inferior to the occurrence in the cefazolin and metronidazole group (3.8%, 21/556). There was no significant difference between the two groups in the secondary outcomes. Conclusion Compared with the cefazolin and metronidazole combination, the ampicillin-sulbactam group is non-inferior as a preoperative prophylactic antibiotic regimen for colorectal surgery.

Keywords

Ampicillin; Antibiotics prophylaxis; cefazolin; Colorectal surgery

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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