Version 1
: Received: 6 August 2023 / Approved: 7 August 2023 / Online: 8 August 2023 (10:16:00 CEST)
How to cite:
Guzzi, P.H.; Cortese, F.; Pedace, E.; Veltri, P. Bioinformatic Analysis of Sex and Age Factors of the Expression
of the Genes Related to Dyslipidemia-based Atherosclerosis.. Preprints2023, 2023080546. https://doi.org/10.20944/preprints202308.0546.v1
Guzzi, P.H.; Cortese, F.; Pedace, E.; Veltri, P. Bioinformatic Analysis of Sex and Age Factors of the Expression
of the Genes Related to Dyslipidemia-based Atherosclerosis.. Preprints 2023, 2023080546. https://doi.org/10.20944/preprints202308.0546.v1
Guzzi, P.H.; Cortese, F.; Pedace, E.; Veltri, P. Bioinformatic Analysis of Sex and Age Factors of the Expression
of the Genes Related to Dyslipidemia-based Atherosclerosis.. Preprints2023, 2023080546. https://doi.org/10.20944/preprints202308.0546.v1
APA Style
Guzzi, P.H., Cortese, F., Pedace, E., & Veltri, P. (2023). Bioinformatic Analysis of Sex and Age Factors of the Expression
of the Genes Related to Dyslipidemia-based Atherosclerosis.. Preprints. https://doi.org/10.20944/preprints202308.0546.v1
Chicago/Turabian Style
Guzzi, P.H., Elisabetta Pedace and Pierangelo Veltri. 2023 "Bioinformatic Analysis of Sex and Age Factors of the Expression
of the Genes Related to Dyslipidemia-based Atherosclerosis." Preprints. https://doi.org/10.20944/preprints202308.0546.v1
Abstract
Dyslipidemia (Dys) is a disease characterised by abnormally high levels of lipids in the
blood. It causes the deposits of lipids on the arterial wall leading to the insurgence of atherosclerosis,
i.e. the increased thickness of arterial walls, which finally increases the risk of cardiovascular diseases.
Dyslipidemia is a comorbidity of Type 2 Diabetes Mellitus (T2DM). A set of genes has been associated with dyslipidemia, but examining the regulation of such genes in age and sex is still an open research
field. In this study, we select from publicly available databases the genes associated with dyslipidemia
and analyse changes in the basal level of such genes by age and sex. Moreover, we also distinct
differential rewiring of the related gene association network in males and females. Our results show
that there exist a set of genes whose expression changes with age in artery tibial, artery aorta and
blood. Moreover, there exist significant differences between sex.
Keywords
Aging; Network Science
Subject
Biology and Life Sciences, Aging
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
