Wójtowicz, D.; Stodolak-Zych, E. Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood. Membranes2023, 13, 762.
Wójtowicz, D.; Stodolak-Zych, E. Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood. Membranes 2023, 13, 762.
Wójtowicz, D.; Stodolak-Zych, E. Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood. Membranes2023, 13, 762.
Wójtowicz, D.; Stodolak-Zych, E. Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood. Membranes 2023, 13, 762.
Abstract
In a blood purification technique continuous renal replacement therapy called CRRT , a porous hollow-fiber polymeric membrane is exposed to prolonged contact with blood. In that condition, like with any other submerged filtration membrane, hemofilter loses its properties over time and use which results in a rapid decline in flux. The most significant reason for this loss is the formation of a biofilm. Protein, blood cells and bacterial cells attach to the membrane surface in complex and fluctuating processes. Anticoagulation allows for longer patency of vascular access and a longer lifespan of the membrane. Other preventive measures include modification of the membrane itself. In this article, we focused on the role of nanoadditives in the mitigation of bio-fouling. Nanoparticles such as graphene, carbon nanotubes, silica effectively change surface properties towards more hydrophilic, affect pore size and distribution, decrease protein adsorption and damage bacteria cells. As a result, membranes modified with nanoparticles show better flow parameters, longer lifespan and increased hemocompatibility.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
