Chua, W.-K.; Hong, Y.-K.; Hu, S.-W.; Fan, H.-C.; Ting, W.-H. A Significant Association between Type 1 Diabetes and Helicobacter Pylori Infection: A Meta-Analysis Study. Medicina 2024, 60, 119, doi:10.3390/medicina60010119.
Chua, W.-K.; Hong, Y.-K.; Hu, S.-W.; Fan, H.-C.; Ting, W.-H. A Significant Association between Type 1 Diabetes and Helicobacter Pylori Infection: A Meta-Analysis Study. Medicina 2024, 60, 119, doi:10.3390/medicina60010119.
Chua, W.-K.; Hong, Y.-K.; Hu, S.-W.; Fan, H.-C.; Ting, W.-H. A Significant Association between Type 1 Diabetes and Helicobacter Pylori Infection: A Meta-Analysis Study. Medicina 2024, 60, 119, doi:10.3390/medicina60010119.
Chua, W.-K.; Hong, Y.-K.; Hu, S.-W.; Fan, H.-C.; Ting, W.-H. A Significant Association between Type 1 Diabetes and Helicobacter Pylori Infection: A Meta-Analysis Study. Medicina 2024, 60, 119, doi:10.3390/medicina60010119.
Abstract
This study aimed to present a systematic meta-analysis examining the association between Helicobacter pylori (H. pylori) infection, hemoglobin A1c levels, and the development of type 1 diabetes mellitus. The initial search identified 451 articles related to the association between H. pylori infection and T1DM. Among them, 14 articles had 2,971 participants meeting the inclusion criteria for advanced meta-analysis. A significant association was observed between H. pylori infection and T1DM, with an odds ratio (OR) of 1.87 (95% confidence interval [CI]: 1.27–2.78, p = 0.002). A subgroup analysis on H. pylori status showed that a longer duration of diabetes diagnosis and higher hemoglobin A1c levels were significantly associated with H. pylori infection (p < 0.001 for both). However, there was no significant association between H. pylori infection and the diagnostic age of diabetes (p = 0.306). These findings contribute to the understanding of the association between H. pylori infection and T1DM, thereby highlighting the potential role of H. pylori in influencing the duration and glycemic control of diabetes.
Keywords
Helicobacter pylori; Type 1 diabetes mellitus; HbA1c; Child; Children; Young patients; Pediatrics; Adolescents; Meta-analysis
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
