Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention

Nebojsa Antonijevic
† ,
Predrag Mitrovic
ORCID logo ,
Nikola Gosnjic
,
Dejan Orlic
,
Sasa Kadija
,
Tanja Ilic Mostic
,
Nebojsa Savic
,
Ljubica Birovljev
,
Zaklina Lekovic
,
Dragan Matic
*,† ORCID logo
†
These authors contributed equally to the work.
Version 1 : Received: 2 August 2023 / Approved: 3 August 2023 / Online: 3 August 2023 (05:25:14 CEST)

A peer-reviewed article of this Preprint also exists.

Antonijevic, N.; Mitrovic, P.; Gosnjic, N.; Orlic, D.; Kadija, S.; Ilic Mostic, T.; Savic, N.; Birovljev, L.; Lekovic, Z.; Matic, D. Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention. J. Pers. Med. 2023, 13, 1344. Antonijevic, N.; Mitrovic, P.; Gosnjic, N.; Orlic, D.; Kadija, S.; Ilic Mostic, T.; Savic, N.; Birovljev, L.; Lekovic, Z.; Matic, D. Successful Caesarean Section on Ticagrelor Treatment One Day after Primary Percutaneous Coronary Intervention. J. Pers. Med. 2023, 13, 1344.

Abstract

Cesarean section is a challenge intervention in patients treated with dual antiplatelet therapy. We present case of 32 years old pregnant woman experiencing large acute myocardial infarction (MI) of anterolateral wall complicated by cardiogenic shock in the 38th week of pregnancy treated with drug-eluting stent implantation and dual antiplatelet therapy (DAPT) consisting of aspirin and ticagrelor. Less than 24 hours after MI delivery started, urgent Caesarean section was indicated. As multiplate aggregometry testing showed a relatively insufficient level of ticagrelor platelet inhibition and a moderate level of aspirin platelet inhibition, Caesarean section was performed without discontinuation of ticagrelor, which was decided due to the need for emergency surgery. Local hemostatic measures including administration of tranexamic acid were applied. The patient did not experience excessive bleeding. A healthy male baby was born. To the best of our knowledge, this is the first reported case of surgery in pregnant women treated with DAPT without ticagrelor discontinuation.

Keywords

ticagrelor; pregnancy; myocardial infarction; aggregometry

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.