Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine

Sehui Kim
ORCID logo ,
Yeji Park
ORCID logo ,
Jeonghun Kim
,
Sohyun Kim
,
Kyungmin Choi
,
Taegyun Kang
,
Inho Lee
,
Yong Taik Lim
,
Soong Ho Um
,
Chul Kim
*
Version 1 : Received: 31 July 2023 / Approved: 31 July 2023 / Online: 1 August 2023 (10:13:40 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, S.; Park, Y.; Kim, J.; Kim, S.; Choi, K.; Kang, T.; Lee, I.; Lim, Y.T.; Um, S.H.; Kim, C. ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine. Vaccines 2023, 11, 1503. Kim, S.; Park, Y.; Kim, J.; Kim, S.; Choi, K.; Kang, T.; Lee, I.; Lim, Y.T.; Um, S.H.; Kim, C. ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine. Vaccines 2023, 11, 1503.

Abstract

Despite numerous studies on cancer treatment, cancer remains a challenging disease to cure, even after decades of research. In recent years, cancer vaccine has emerged as a promising approach for cancer treatment, offering few unexpected side effects compared to existing therapies. How-ever, cancer vaccine faces obstacles to commercialization due to its low efficacy. Particularly, the Toll-like receptor (TLR) adjuvant system, specifically the TLR 7/8 agonist, has shown potential for activating Th1 immunity, which stimulates both innate and adaptive immune responses through T cells. In this study, we developed ProLNG-S, a cholesterol-conjugated form of resiquimod (R848), to enhance immune efficacy by stimulating the immune system and reducing toxicity. ProLNG-S was formulated as ProLNG-001, a positively charged liposome, and co-administered with oval-bumin (OVA) protein in the B16-OVA model. ProLNG-001 effectively targeted secondary lym-phoid organs, resulting in a robust systemic anti-tumor immune response and tumor-specific T cell activation. Consequently, ProLNG-001 demonstrated potential for preventing tumor progression and improving survival compared to AS01 by enhancing anti-tumor immunity.

Keywords

cancer vaccine; adjuvant; nanovaccines; TLR 7/8 agonist; melanoma; immunomodulator

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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