Version 1
: Received: 29 July 2023 / Approved: 31 July 2023 / Online: 1 August 2023 (02:48:42 CEST)
How to cite:
Kang, H.; Lee, K. Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis. Preprints2023, 2023072131. https://doi.org/10.20944/preprints202307.2131.v1
Kang, H.; Lee, K. Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis. Preprints 2023, 2023072131. https://doi.org/10.20944/preprints202307.2131.v1
Kang, H.; Lee, K. Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis. Preprints2023, 2023072131. https://doi.org/10.20944/preprints202307.2131.v1
APA Style
Kang, H., & Lee, K. (2023). Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis. Preprints. https://doi.org/10.20944/preprints202307.2131.v1
Chicago/Turabian Style
Kang, H. and Kyung-Yil Lee. 2023 "Pathophysiology of Virus Infections: The Protein-Homeostasis-System Hypothesis" Preprints. https://doi.org/10.20944/preprints202307.2131.v1
Abstract
The etiological agent of various viral diseases has been identified, and clinical characteristics and complications of each disease are well known. In general, a viral disease appears as acute systemic inflammatory disease, but after acute infection, some patients remain asymptomatic carriers or suffer chronic viral diseases, suggesting that the phenomena are unavoidable processes for viruses’ coexistence with their hosts as virome in microbiota of human species. Although each viral disease has been described as having different pathophysiology, the host's control systems, including immune systems, against the insults from any viral infections, have the same components in previously healthy hosts. Therefore, considering the characteristics of the life cycle of viruses being dependent on the host cell and the same immune components of the host, it is reasonable assumption that there is a common immune mechanism to respond to the insults from all viral diseases. The authors discuss on the characteristics of virus infection and unresolved issues in viral diseases and propose a rationale of early immune modulators for acute insults from viral diseases based on our clinical experiences and the protein-homeostasis-system hypothesis.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
