You, F.; Harakawa, Y.; Yoshikawa, T.; Inufusa, H. Why Does the Antioxidant Complex Twendee X® Prevent Dementia? Int. J. Mol. Sci.2023, 24, 13018.
You, F.; Harakawa, Y.; Yoshikawa, T.; Inufusa, H. Why Does the Antioxidant Complex Twendee X® Prevent Dementia? Int. J. Mol. Sci. 2023, 24, 13018.
You, F.; Harakawa, Y.; Yoshikawa, T.; Inufusa, H. Why Does the Antioxidant Complex Twendee X® Prevent Dementia? Int. J. Mol. Sci.2023, 24, 13018.
You, F.; Harakawa, Y.; Yoshikawa, T.; Inufusa, H. Why Does the Antioxidant Complex Twendee X® Prevent Dementia? Int. J. Mol. Sci. 2023, 24, 13018.
Abstract
Alzheimer's disease (AD) is a complex disease involving multiple factors such as amyloid plaque formation, mitochondrial dysfunction, telomere length, and oxidative stress. As the disease began 20 years before the onset of clinical symptoms, treatment of AD after its onset is likely to be too late to have a significant effect. Therefore, prevention from an early stage is important. Twendee X®︎ (TwX, Oxicut®︎) is an antioxidant supplement consisting of eight ingredients. TwX has been proven to prevent dementia in patients with mild cognitive impairment (MCI) in a multicenter, randomized, double-blind, placebo-controlled, prospective intervention trial. To elucidate the mechanisms of TwX on brain and cellular function, TwX was administered in in vitro experiments and in a C57BL/6 old wild-type, and spontaneous hyperglycemia model with accelerated cognitive decline, and its effects on diabetes, brain autophagy, neurogenesis, and telomere length were evaluated in comparison with those of the non-treated groups. TwX protected mitochondria from oxidative stress with higher antioxidant capacity than a single antioxidant. TwX not only lowered blood glucose levels, but also suppressed reduction of brain neurogenesis and loss of autophagy. Telomeres in aged mice were significantly longer than those in non-TwX-treated mice. Development of dementia is based on many factors of brain function. TwX was suggested to prevent dementia not only by its antioxidant effects, but also by its effects on diabetes, brain neurogenesis, telomere deficiency, and energy production.
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