Sagoe, P.N.K.; Velázquez, E.J.M.; Espiritusanto, Y.M.; Gilbert, A.; Orado, T.; Wang, Q.; Jain, E. Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application. Molecules2023, 28, 6679.
Sagoe, P.N.K.; Velázquez, E.J.M.; Espiritusanto, Y.M.; Gilbert, A.; Orado, T.; Wang, Q.; Jain, E. Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application. Molecules 2023, 28, 6679.
Sagoe, P.N.K.; Velázquez, E.J.M.; Espiritusanto, Y.M.; Gilbert, A.; Orado, T.; Wang, Q.; Jain, E. Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application. Molecules2023, 28, 6679.
Sagoe, P.N.K.; Velázquez, E.J.M.; Espiritusanto, Y.M.; Gilbert, A.; Orado, T.; Wang, Q.; Jain, E. Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application. Molecules 2023, 28, 6679.
Abstract
Polymeric microparticles of polyethyleneglycol-polylactic acid-co-glycolic acid (PEG-PLGA) are widely used as drug carriers for a variety of applications due to their unique characteristics. Herein, we developed a novel method for the synthesis of uniformly sized microparticles via coaxial flow-phase separation. The study evaluated the effect of various process parameters on microparticle size and polydispersity including polymer concentration, stirring rate, surfactant concentration, and the organic/aqueous phase flow rate and volume ratio. The results demonstrated that stirring rate and polymer concentration had the most significant impact on the mean particle size and distribution whereas surfactant concentration had the most substantial impact on the morphology of particles. Several microparticle formulations yielding particle sizes in the range of (5-50 µm), morphology, and concentration were synthesized as a demonstration of the tunability and scalability of this method. Notably, by controlling the process parameters microparticles of less than ~ 7 μm could be made using polymer concentrations varying by an order of magnitude. Finally, we demonstrated the tunability and scalability of this method by showing a 10-fold increase in encapsulation efficiency, a 3-fold increase in drug loading of a model hydrophilic drug, and modified release kinetics in microparticle formulations of comparable sizes but different polymer concentrations.
Keywords
Microparticles; PEG; PLGA; coaxial flow; phase separation; drug delivery
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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