Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets

Seyed Hossein Shahcheraghi
,
Elmira Roshani Asl
,
Malihe Lotfi
,
Jamshid Ayatollahi
,
Seyed Hossein Khaleghinejad
,
Alaa A.A. Aljabali
ORCID logo ,
Hamid Bakshi
,
Mohamed El-Tanani
ORCID logo ,
Najwane Said-Sadier
ORCID logo ,
Abdulmajeed G. Almutary
,
Ángel Serrano-Aroca
ORCID logo ,
Vijay Mishra
ORCID logo ,
Yachana Mishra
ORCID logo ,
Rohit Goyal
,
Altijana Hromić-Jahjefendić
,
Vladimir N. Uversky
* ORCID logo ,
Marzieh Lotfi
* ,
Murtaza M. Tambuwala
*
Version 1 : Received: 20 July 2023 / Approved: 21 July 2023 / Online: 24 July 2023 (10:51:59 CEST)

A peer-reviewed article of this Preprint also exists.

Shahcheraghi, S.H.; Roshani Asl, E.; Lotfi, M.; Ayatollahi, J.; Khaleghinejad, S.H.; Aljabali, A.A.; Bakshi, H.A.; El-Tanani, M.; Charbe, N.; Serrano-Aroca, Á.; et al. Non-Coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets. CNS & Neurological Disorders - Drug Targets 2024, 23, doi:10.2174/0118715273277458231213063147. Shahcheraghi, S.H.; Roshani Asl, E.; Lotfi, M.; Ayatollahi, J.; Khaleghinejad, S.H.; Aljabali, A.A.; Bakshi, H.A.; El-Tanani, M.; Charbe, N.; Serrano-Aroca, Á.; et al. Non-Coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets. CNS & Neurological Disorders - Drug Targets 2024, 23, doi:10.2174/0118715273277458231213063147.

Abstract

Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation. The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1, and Hey1, thereby promoting cellular proliferation and differentiation. Recent research has highlighted the regulatory role of non-coding RNAs (ncRNAs) in modulating Notch signaling by targeting critical mRNA expression at the post-transcriptional or transcriptional levels. Specifically, various types of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to control multiple target genes and significantly contribute to the carcinogenesis of GBM. Furthermore, these ncRNAs hold promise as prognostic and predictive markers for GBM. This review aims to summarize the latest studies investigating the regulatory effects of ncRNAs on the Notch signaling pathway in GBM.

Keywords

Glioblastoma, Notch signaling, lncRNAs, miRNAs

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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