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Sedation quality and cardiorespiratory, echocardiographic, radiographic and electrocardiographic effects of intramuscular alfaxalone and butorphanol in Galgo Español dogs
Fernández Castañer, J.; Quirós Carmona, S.; Martínez Bernal, C.; Morgaz Rodríguez, J.; Navarrete Calvo, R.; Granados Machuca, M.M. Sedation Quality and Cardiorespiratory, Echocardiographic, Radiographic and Electrocardiographic Effects of Intramuscular Alfaxalone and Butorphanol in Spanish Greyhound Dogs. Animals2023, 13, 2937.
Fernández Castañer, J.; Quirós Carmona, S.; Martínez Bernal, C.; Morgaz Rodríguez, J.; Navarrete Calvo, R.; Granados Machuca, M.M. Sedation Quality and Cardiorespiratory, Echocardiographic, Radiographic and Electrocardiographic Effects of Intramuscular Alfaxalone and Butorphanol in Spanish Greyhound Dogs. Animals 2023, 13, 2937.
Fernández Castañer, J.; Quirós Carmona, S.; Martínez Bernal, C.; Morgaz Rodríguez, J.; Navarrete Calvo, R.; Granados Machuca, M.M. Sedation Quality and Cardiorespiratory, Echocardiographic, Radiographic and Electrocardiographic Effects of Intramuscular Alfaxalone and Butorphanol in Spanish Greyhound Dogs. Animals2023, 13, 2937.
Fernández Castañer, J.; Quirós Carmona, S.; Martínez Bernal, C.; Morgaz Rodríguez, J.; Navarrete Calvo, R.; Granados Machuca, M.M. Sedation Quality and Cardiorespiratory, Echocardiographic, Radiographic and Electrocardiographic Effects of Intramuscular Alfaxalone and Butorphanol in Spanish Greyhound Dogs. Animals 2023, 13, 2937.
Abstract
The quality of sedation and changes in cardiorespiratory variables after the intramuscular administration of alfaxalone and butorphanol in Galgo Español dogs were evaluated. Twenty-one adult dogs were included. The dogs received alfaxalone (2 mg/kg) and butorphanol (0,2 mg/kg) intramuscularly. Sedation scoring, cardiorespiratory parameters (including blood gas analysis), echocardiography, thoracic radiography and electrocardiography were performed before sedation and 30 minutes after drug administration. Moderate sedation was observed, and side effects, such as tremors, nystagmus and auditory hyperesthesia, were noticed. Statistically significant changes in heart rate, invasive blood pressure, pH, arterial saturation of O2 and partial pressure of O2 and CO2 were found. Echocardiographic variables, including end-diastolic volume, left ventricular diameter in diastole, aortic and pulmonic flow, diastolic transmitral flow and left atrial/aortic ratio, and electrocardiography parameters, including PQ interval and QT interval, showed statistically significant changes. In conclusion, the intramuscular administration of alfaxalone and butorphanol to healthy dogs produced moderate sedation with mild cardiorespiratory, echocardiographic and electrocardiographic changes, without alterations in cardiac size on X-ray images.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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