Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Current Challenges and Future Directions in the Management of Inflammatory Breast Cancer: A Review

Paolo Izzo
* ORCID logo ,
Luciano Izzo
,
Andrea Polistena
ORCID logo ,
Simone Sibio
ORCID logo ,
Massimo Codacci-Pisanelli
,
Daniele Crocetti
,
Paolo Meloni
,
Pierfrancesco Di Cello
,
Claudia De Intinis
ORCID logo ,
Sara Izzo
Version 1 : Received: 19 July 2023 / Approved: 20 July 2023 / Online: 21 July 2023 (12:39:42 CEST)

How to cite: Izzo, P.; Izzo, L.; Polistena, A.; Sibio, S.; Codacci-Pisanelli, M.; Crocetti, D.; Meloni, P.; Di Cello, P.; De Intinis, C.; Izzo, S. Current Challenges and Future Directions in the Management of Inflammatory Breast Cancer: A Review. Preprints 2023, 2023071462. https://doi.org/10.20944/preprints202307.1462.v1 Izzo, P.; Izzo, L.; Polistena, A.; Sibio, S.; Codacci-Pisanelli, M.; Crocetti, D.; Meloni, P.; Di Cello, P.; De Intinis, C.; Izzo, S. Current Challenges and Future Directions in the Management of Inflammatory Breast Cancer: A Review. Preprints 2023, 2023071462. https://doi.org/10.20944/preprints202307.1462.v1

Abstract

(1) Background: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that poses unique management challenges. This review aims to synthesize the current literature on IBC, focusing on diagnosis, treatment, and prognosis, while highlighting recent advances and ongoing issues in patient management.; (2) Methods: We outline the typical clinical presentation and diagnostic criteria of IBC. Additionally, we detail the main therapeutic strategies, including neoadjuvant chemotherapy, surgery, radiation therapy, targeted therapies, hormonal therapies, and emerging treatments such as immunotherapy. The review is based on a comprehensive analysis of the existing literature.; (3) Results: Despite advancements in systemic therapy and a better understanding of IBC biology, the prognosis for patients with IBC remains poor. The overall survival rate has shown only marginal improvement over the past few decades. Future research directions, including the identification of novel biomarkers for early detection and personalized medicine strategies, are identified. The need for more high-quality clinical trials to address the challenges in IBC management is emphasized.; (4) Conclusions: Managing IBC is a complex task that necessitates multidisciplinary care and patient-centered communication. This review provides clinicians and researchers with a comprehensive overview of the current challenges and future directions in IBC management. The goal is to guide treatment decisions and inform further research, ultimately improving patient outcomes and prognosis.

Keywords

inflammatory breast cancer (IBC); review; immunotherapy; targeted therapy; tumor microenvironment

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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