Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The First Case of Zika Virus Disease in Guinea: Description, Virus Isolation, Sequencing and Seroprevalence in Local Population

Roman Bayandin
* ORCID logo ,
Marat T. Makenov
ORCID logo ,
Sanaba Boumbaly
,
Olga A. Stukolova
,
Anastasia V. Gladysheva
ORCID logo ,
Andrey V. Shipovalov
,
Maksim O. Skarnovich
,
Ousmane Camara
,
Aboubacar Hady Toure
,
Victor A. Svyatchenko
,
Alexander N. Shvalov
,
Vladimir A. Ternovoi
,
Mamadou Y. Boiro
,
Alexander P. Agafonov
,
Lyudmila S. Karan
Version 1 : Received: 19 July 2023 / Approved: 20 July 2023 / Online: 20 July 2023 (04:51:12 CEST)

A peer-reviewed article of this Preprint also exists.

Bayandin, R.B.; Makenov, M.T.; Boumbaly, S.; Stukolova, O.A.; Gladysheva, A.V.; Shipovalov, A.V.; Skarnovich, M.O.; Camara, O.; Toure, A.H.; Svyatchenko, V.A.; Shvalov, A.N.; Ternovoi, V.A.; Boiro, M.Y.; Agafonov, A.P.; Karan, L.S. The First Case of Zika Virus Disease in Guinea: Description, Virus Isolation, Sequencing, and Seroprevalence in Local Population. Viruses 2023, 15, 1620. Bayandin, R.B.; Makenov, M.T.; Boumbaly, S.; Stukolova, O.A.; Gladysheva, A.V.; Shipovalov, A.V.; Skarnovich, M.O.; Camara, O.; Toure, A.H.; Svyatchenko, V.A.; Shvalov, A.N.; Ternovoi, V.A.; Boiro, M.Y.; Agafonov, A.P.; Karan, L.S. The First Case of Zika Virus Disease in Guinea: Description, Virus Isolation, Sequencing, and Seroprevalence in Local Population. Viruses 2023, 15, 1620.

Abstract

Zika virus (ZIKV) is a widespread mosquito-borne pathogen. Phylogenetically, two lineages of the ZIKV are distinguished: African and Asian-American. The latter became the cause of the 2015-2016 pandemic with severe defeat to newborns. In West African countries the African lineage has been found, but there is evidence of the emergence of Asian-American lineage in Cape Verde and Angola. This highlights the need not only to monitor the ZIKV, but also to sequence the isolates. In this article, we present a case report of Zika fever in a pregnant woman from Guinea, identified in 2018. Viral RNA was detected by qRT-PCR in serum sample. In addition, seroconversion of anti-Zika IgM and IgG antibodies was detected in repeated blood samples. Subsequently, the virus was isolated in C6/36 cell line. The detected ZIKV belonged to the African lineage, the Nigerian sublineage. The strains with the closest sequences were isolated from mosquitoes in Senegal in 2011 and 2015. In addition, we conducted serological screening of 116 blood samples collected from patients presenting to the hospital of Faranah with fevers during the period 2018-2021. As a result, it was found that IgM-positive patients occurred each year, seroprevalence varied between 5.6% and 17.1%.

Keywords

Zika virus; seroprevalence; flavivirus; arbovirus; fever; mosquito-borne virus; vector-borne virus

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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