Version 1
: Received: 17 July 2023 / Approved: 18 July 2023 / Online: 18 July 2023 (11:55:05 CEST)
How to cite:
Razin, E.; Abu-rahmah, R.; Nechushtan, H.; Hidmi, S.; Meirovitz, A.; Peretz, T. The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer. Preprints2023, 2023071232. https://doi.org/10.20944/preprints202307.1232.v1
Razin, E.; Abu-rahmah, R.; Nechushtan, H.; Hidmi, S.; Meirovitz, A.; Peretz, T. The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer. Preprints 2023, 2023071232. https://doi.org/10.20944/preprints202307.1232.v1
Razin, E.; Abu-rahmah, R.; Nechushtan, H.; Hidmi, S.; Meirovitz, A.; Peretz, T. The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer. Preprints2023, 2023071232. https://doi.org/10.20944/preprints202307.1232.v1
APA Style
Razin, E., Abu-rahmah, R., Nechushtan, H., Hidmi, S., Meirovitz, A., & Peretz, T. (2023). The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer. Preprints. https://doi.org/10.20944/preprints202307.1232.v1
Chicago/Turabian Style
Razin, E., Amichay Meirovitz and Tamar Peretz. 2023 "The Role of NUDT2 in the Functioning of Human Triple Negative Breast Cancer" Preprints. https://doi.org/10.20944/preprints202307.1232.v1
Abstract
The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5', 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in the human invasion ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly high expression of Nudt2 in the human invasion ductal carcinoma tissues was observed in our study. Knockdown of Nudt2 in TNBC cell lines showed a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest. A significant reduction in the migration and invasion of Nudt2 knockdown TNBC cell lines was also observed. The effect of Nudt2 knockdown in the TNBC cell lines on tumorigenicity and anchorage-independent growth was assessed, where significant reductions in the Nudt2 knockdown TNBC cell lines were found. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.
Keywords
Nudt2, TNBC, anchorage-independent growth, migration and invasion.
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
