Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neurofilament Light Chain Levels Increase With Age and Are Associated With Worst Physical Function and Body Composition in Men but Not in Women

Xavier Capo
,
Aina Galmes-Panades
,
Cayetano Navas-Enamorado
,
Ana Ortega-Moral
,
Silvia Marin
ORCID logo ,
Marta Cascante
ORCID logo ,
Andres Sanchez-Polo
ORCID logo ,
Luis Masmiquel
ORCID logo ,
Margalida Torrens-Mas
,
Marta Gonzalez-Freire
* ORCID logo
Version 1 : Received: 17 July 2023 / Approved: 18 July 2023 / Online: 18 July 2023 (14:18:55 CEST)

A peer-reviewed article of this Preprint also exists.

Capo, X.; Galmes-Panades, A.M.; Navas-Enamorado, C.; Ortega-Moral, A.; Marín, S.; Cascante, M.; Sánchez-Polo, A.; Masmiquel, L.; Torrens-Mas, M.; Gonzalez-Freire, M. Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women. Int. J. Mol. Sci. 2023, 24, 12751. Capo, X.; Galmes-Panades, A.M.; Navas-Enamorado, C.; Ortega-Moral, A.; Marín, S.; Cascante, M.; Sánchez-Polo, A.; Masmiquel, L.; Torrens-Mas, M.; Gonzalez-Freire, M. Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women. Int. J. Mol. Sci. 2023, 24, 12751.

Abstract

Background: This study aimed to assess the relationship between age-related changes in Neuro-filament Light Chain (NFL), a marker of neuronal function, and various factors including muscle function, body composition, and metabolomic markers. Methods: The study included 40 partici-pants, aged 20 to 85 years. NFL levels were measured, and muscle function, body composition, and metabolomic markers were assessed. Results: NFL levels increased significantly with age, particularly in men. Negative correlations were found between NFL levels and measures of mus-cle function, such as grip strength, walking speed, and chair test performance, indicating a decline in muscle performance with increasing NFL. These associations were more pronounced in men. NFL levels also negatively correlated with muscle quality in men, as measured by 50 kHz phase angle. In terms of body composition, NFL was positively correlated with markers of fat mass and negatively correlated with markers of muscle mass, predominantly in men. Metabolomic analy-sis revealed significant associations between NFL levels and specific metabolites, with gen-der-dependent relationships observed. Conclusions: This study provides insights into the rela-tionship between circulating serum NFL, muscle function, and aging. The findings highlight gen-der differences and contribute to our understanding of age-related changes in neuronal function and their impact on muscle health.

Keywords

Aging; neurodegeneration; metabolomics; NFL; muscle function; gender dimorphism

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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