Lipid Peroxidation and Antioxidant Protection

Luca Valgimigli

doi:10.20944/preprints202307.1130.v2

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preprints.org > chemistry and materials science > medicinal chemistry > doi: 10.20944/preprints202307.1130.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Lipid Peroxidation and Antioxidant Protection

Luca Valgimigli

Version 1 : Received: 14 July 2023 / Approved: 17 July 2023 / Online: 18 July 2023 (08:57:23 CEST)
Version 2 : Received: 17 August 2023 / Approved: 18 August 2023 / Online: 18 August 2023 (10:02:12 CEST)

A peer-reviewed article of this Preprint also exists.

Valgimigli, L. Lipid Peroxidation and Antioxidant Protection. Biomolecules 2023, 13, 1291. Valgimigli, L. Lipid Peroxidation and Antioxidant Protection. Biomolecules 2023, 13, 1291.

Abstract

Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and to its role in secondary damage to other biomolecules, such as proteins. The chemistry of LP and its biological consequences are reviewed with focus on the kinetics of the various processes, which helps understand the mechanisms and efficacy of antioxidant strategies. The main types of antioxidants are discussed in terms of structure-activity rationalization, with focus on mechanism and kinetics, as well as on their potential role in modulating ferroptosis. Phenols, pyri(mi)dinols, antioxidants based on heavy chalcogens (Se and Te), diarylamines, ascorbate and others are addressed, along with the latest unconventional antioxidant strategies based on the double-sided role of the superoxide/hydroperoxyl radical system.

Keywords

autoxidation; peroxyl radicals; hydroperoxyl radicals; kinetics, antioxidants; phenols; catechols; nitroxides; thiols; pyridinols

Subject

Chemistry and Materials Science, Medicinal Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 18 August 2023
Commenter: Luca Valgimigli
Commenter's Conflict of Interests: Author

Comment: The manuscript as been revised as requested by the reviewers and academic Editor hangling it at Biomolecules.
The revised version is identical to that submitted today at Biomolecules

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