Version 1
: Received: 17 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (10:11:25 CEST)
How to cite:
Wang, C.; Chen, Y.; Hu, S.; Liu, X. Insights into the Function of ESCRT and Its Role in Enveloped Virus Infection. Preprints2023, 2023071097. https://doi.org/10.20944/preprints202307.1097.v1
Wang, C.; Chen, Y.; Hu, S.; Liu, X. Insights into the Function of ESCRT and Its Role in Enveloped Virus Infection. Preprints 2023, 2023071097. https://doi.org/10.20944/preprints202307.1097.v1
Wang, C.; Chen, Y.; Hu, S.; Liu, X. Insights into the Function of ESCRT and Its Role in Enveloped Virus Infection. Preprints2023, 2023071097. https://doi.org/10.20944/preprints202307.1097.v1
APA Style
Wang, C., Chen, Y., Hu, S., & Liu, X. (2023). Insights into the Function of ESCRT and Its Role in Enveloped Virus Infection. Preprints. https://doi.org/10.20944/preprints202307.1097.v1
Chicago/Turabian Style
Wang, C., Shunlin Hu and Xiufan Liu. 2023 "Insights into the Function of ESCRT and Its Role in Enveloped Virus Infection" Preprints. https://doi.org/10.20944/preprints202307.1097.v1
Abstract
The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs). It participates in various cellular processes, including lipid bilayer remodeling, cytoplasmic separation, autophagy, membrane fission and remodeling, plasma membrane repair, as well as the invasion, budding, and release of certain enveloped viruses. The ESCRT complex consists of five complexes, ESCRT-0 to ESCRT-III and VPS4, along with several accessory proteins. ESCRT-0 to ESCRT-II form soluble complexes that shuttle between the cytoplasm and membranes, mainly responsible for recruiting and transporting membrane proteins and viral particles, as well as recruiting ESCRT-III for membrane neck scission. ESCRT-III, a soluble monomer, directly participates in vesicle scission and release, while VPS4 hydrolyzes ATP to provide energy for ESCRT-III complex disassembly, enabling recycling. Studies have confirmed the hijacking of ESCRT complexes by enveloped viruses to facilitate their entry, replication, and budding. Recent research has focused on the interaction between various components of the ESCRT complex and different viruses. In this review, we discuss how different viruses hijack specific ESCRT regulatory proteins to impact the viral life cycle, aiming to explore commonalities in the interaction between viruses and the ESCRT system.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
