Han, D., Wang, M., Dong, N., Zhang, J., Li, D., Ma, X., ... & Wang, C. Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment. Journal of controlled release: official journal of the Controlled Release Society, S0168-3659.
Han, D., Wang, M., Dong, N., Zhang, J., Li, D., Ma, X., ... & Wang, C. Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment. Journal of controlled release: official journal of the Controlled Release Society, S0168-3659.
Han, D., Wang, M., Dong, N., Zhang, J., Li, D., Ma, X., ... & Wang, C. Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment. Journal of controlled release: official journal of the Controlled Release Society, S0168-3659.
Han, D., Wang, M., Dong, N., Zhang, J., Li, D., Ma, X., ... & Wang, C. Selective homing of brain-derived reconstituted lipid nanoparticles to cerebral ischemic area enables improved ischemic stroke treatment. Journal of controlled release: official journal of the Controlled Release Society, S0168-3659.
Abstract
Lipid nanoparticles (LNPs) are promising carriers for constructing drug delivery systems (DDSs) in disease treatments. Previous studies have suggested that lipid composition and biophysical properties of LNPs can significantly impact their interaction with cells and tissues, allowing for the development of suitable LNPs for precise drug delivery. Our previous study proposed the concept and facile preparation of reconstituted lipid nanoparticles (rLNPs), which not only have the advantages of traditional LNPs but also contain the lipids of mother cell/tissue. In this study, we have found that brain-derived rLNPs (B-rLNPs) can have much better accumulation to the ischemic area of the ischemic stroke (IS) model than liver-derived rLNPs (L-rLNPs). This homing effect hopefully makes rLNPs a useful tool for developing highly accessible devices with homologous targeting ability for precise drug delivery.
Copyright:
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