Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Anesthetic Management and Complications of Total Hip Arthroplasty in Gaucher Disease: A Control-matched Retrospective-Cohort Study

Ariel Grass
* ORCID logo ,
Eyal Riemer
,
Ari Zimran
ORCID logo ,
Shoshana Revel-Vilk
ORCID logo ,
Andres Freundlich
,
Ehud Lebel
ORCID logo ,
Alexander Ioscovich
Version 1 : Received: 5 July 2023 / Approved: 13 July 2023 / Online: 14 July 2023 (11:25:28 CEST)

A peer-reviewed article of this Preprint also exists.

Grass, A.; Riemer, E.; Zimran, A.; Revel-Vilk, S.; Freundlich, A.; Lebel, E.; Ioscovich, A. Anesthetic Approaches and Perioperative Complications of Total Hip Arthroplasty in Gaucher Disease: A Control-Matched Retrospective-Cohort Study. Life 2023, 13, 1716. Grass, A.; Riemer, E.; Zimran, A.; Revel-Vilk, S.; Freundlich, A.; Lebel, E.; Ioscovich, A. Anesthetic Approaches and Perioperative Complications of Total Hip Arthroplasty in Gaucher Disease: A Control-Matched Retrospective-Cohort Study. Life 2023, 13, 1716.

Abstract

Gaucher Disease's (GD) pathophysiology generates anesthetic concerns in Total Hip joint Arthroplasty (THA), and due to its rareness, data on perioperative risks is scarce. This 22-year study at a large reference center addresses anesthetic management and perioperative outcomes in GD. This retrospective-cohort study assessed anesthetic success and safety in 30 THA patients, comparing them with a control-matched group. Data on clinical characteristics, perioperative events, and outcomes were collected. The primary outcome was difficult anesthesia-initiation incidence. Secondary outcomes were difficult intraoperative course and hemodynamic management, and the development of postoperative-complications. The age, sex, weight, body mass index, primary-to-revision hip arthroplasty ratio were similar in both groups. The mean age was 48±13 years. Ten arthroplasties were revision while twenty were primary. There was no significant difference at all-type anesthesia first initiation attempt success. No particular preference by staff anesthetists for general anesthesia or neuraxial procedures was observed. The GD group showed significantly higher mean intraoperative packed red blood cell units administered (0.73 vs 0.18);(p= 0.038)), higher intraoperative and postoperative platelet transfusion incidence (5/30 [16.7%] vs. 0/56 [0.00%];p=0.004) and (3/30 [10%] vs 0/56 [0%];p=0.040) and longer mean recovery-room length-of-stay (426±412 vs 175±140;p=0.004). Postoperative complications were not significantly different.

Keywords

Intraoperative Complications; Gaucher Disease; General Anesthesia; Regional Anesthesia; Total Hip Arthroplasty,

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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