Version 1
: Received: 13 July 2023 / Approved: 13 July 2023 / Online: 14 July 2023 (09:04:41 CEST)
How to cite:
Ren, K.; Shi, M.; Cheng, Y.; Zhang, W.; Wang, Y.; Xia, X.-Q. The Application of Zebrafish Model in the Study of Idiopathic Scoliosis. Preprints2023, 2023070957. https://doi.org/10.20944/preprints202307.0957.v1
Ren, K.; Shi, M.; Cheng, Y.; Zhang, W.; Wang, Y.; Xia, X.-Q. The Application of Zebrafish Model in the Study of Idiopathic Scoliosis. Preprints 2023, 2023070957. https://doi.org/10.20944/preprints202307.0957.v1
Ren, K.; Shi, M.; Cheng, Y.; Zhang, W.; Wang, Y.; Xia, X.-Q. The Application of Zebrafish Model in the Study of Idiopathic Scoliosis. Preprints2023, 2023070957. https://doi.org/10.20944/preprints202307.0957.v1
APA Style
Ren, K., Shi, M., Cheng, Y., Zhang, W., Wang, Y., & Xia, X. Q. (2023). The Application of Zebrafish Model in the Study of Idiopathic Scoliosis. Preprints. https://doi.org/10.20944/preprints202307.0957.v1
Chicago/Turabian Style
Ren, K., Yaping Wang and Xiao-Qin Xia. 2023 "The Application of Zebrafish Model in the Study of Idiopathic Scoliosis" Preprints. https://doi.org/10.20944/preprints202307.0957.v1
Abstract
Idiopathic scoliosis (IS) is an unexplained dysplasia of the spine that can occur at any age, with idiopathic scoliosis making up the largest proportion of the total population worldwide, approximately 2-3%. Scoliosis is not just a cosmetic defect, but the development of the spinal deformity can lead to cardiovascular and respiratory lesions, often resulting in serious health problems. Treatment of the condition usually involves major surgery, which is both a physical and financial burden for patients. In order to clarify the aetiology of IS and provide a theoretical basis for new diagnostic and treatment methods IS, it is important to use different animal models for experiments. Zebrafish is an emerging model animal with a short reproductive cycle, minimal breeding expenses, and other beneficial traits including in vitro fertilisation, in vitro development, and embryo transparency. As a result, genetic alteration and observation are simpler than with traditional model animals. This study examines the history of animal models for IS research, focuses on the benefits and drawbacks of zebrafish as an IS model and the advances it provides to IS research, and anticipates zebrafish application prospects in IS research.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
