The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication and Implications for Peripheral Nerve Regeneration

Teng Wan; Yi-Lin Wang; Feng-Shi Zhang; Xiao-Meng Zhang; Yi-Chong Zhang; Hao-ran Jiang; Meng Zhang; Pei-Xun Zhang

doi:10.20944/preprints202307.0888.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints202307.0888.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication and Implications for Peripheral Nerve Regeneration

Version 1 : Received: 12 July 2023 / Approved: 12 July 2023 / Online: 13 July 2023 (10:05:55 CEST)

A peer-reviewed article of this Preprint also exists.

Wan, T.; Wang, Y.-L.; Zhang, F.-S.; Zhang, X.-M.; Zhang, Y.-C.; Jiang, H.-R.; Zhang, M.; Zhang, P.-X. The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration. Int. J. Mol. Sci. 2023, 24, 14132. Wan, T.; Wang, Y.-L.; Zhang, F.-S.; Zhang, X.-M.; Zhang, Y.-C.; Jiang, H.-R.; Zhang, M.; Zhang, P.-X. The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration. Int. J. Mol. Sci. 2023, 24, 14132.

Abstract

The porous structure is an important three-dimensional morphological feature of the peripheral nerve guidance conduit (NGC), which permits infiltration of cells, nutrients, and molecular signals, and the discharge of metabolic waste. Porous structures with precisely customised pore sizes, porosities, and connectivities were used to construct fully permeable, semi-permeable, and asymmetric peripheral NGCs to replace traditional nerve autografts in treatment of long-segment peripheral nerve injury. In this review, the features of porous structures and classification of NGCs based on these characteristics are discussed. Common methods for constructing 3D porous NGCs in current research are described, as well as the pore characteristics and the parameters used to tune the pores. The effects of the porous structure on the physical properties of NGCs including biodegradation, mechanical performance, and permeability were analysed. Pore structure affects the biological behaviour of Schwann cells, macrophages, fibroblasts, and vascular endothelial cells during peripheral nerve regeneration. Construction of ideal porous structures is a significant advancement in the regeneration of peripheral nerve tissue engineering materials. The purpose of this review is to generalise, summarise, and analyse the preparation methods for porous NGCs and their biological functions in promoting peripheral nerve regeneration to guide development of medical nerve repair materials.

Keywords

porous structure; peripheral nerve guidance conduit; peripheral nerve regeneration; permeability

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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