Kim, J.O.; Ryu, C.S.; Lee, J.Y.; Ko, E.J.; Ha, Y.H.; Sung, J.H.; Hwang, T.S.; Kim, I.J.; Kim, N.K. Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease. Int. J. Mol. Sci.2023, 24, 12591.
Kim, J.O.; Ryu, C.S.; Lee, J.Y.; Ko, E.J.; Ha, Y.H.; Sung, J.H.; Hwang, T.S.; Kim, I.J.; Kim, N.K. Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease. Int. J. Mol. Sci. 2023, 24, 12591.
Kim, J.O.; Ryu, C.S.; Lee, J.Y.; Ko, E.J.; Ha, Y.H.; Sung, J.H.; Hwang, T.S.; Kim, I.J.; Kim, N.K. Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease. Int. J. Mol. Sci.2023, 24, 12591.
Kim, J.O.; Ryu, C.S.; Lee, J.Y.; Ko, E.J.; Ha, Y.H.; Sung, J.H.; Hwang, T.S.; Kim, I.J.; Kim, N.K. Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease. Int. J. Mol. Sci. 2023, 24, 12591.
Abstract
Coronary artery disease (CAD) is a prevalent cardiovascular condition characterized by the accumulation of plaque within coronary arteries. This plaque accumulation obstructs blood flow to the heart, resulting in a heart attack. While distinct features of CAD have been identified, its causes remain largely unclear, with the exception of environmental and nutritional factors. This study aimed to investigate the connection between genetic factors and CAD, focusing on the thymidylate synthase (TS) gene, a gene involved in one-carbon metabolism. Therefore, our research targeted single nucleotide polymorphisms that could potentially impact TS gene expression and lead to dysfunction. Our findings strongly associate the TS 1100T>C and 1170A>G genotypes with CAD susceptibility. We observed that TS 1100T>C polymorphisms increased disease susceptibility in several groups, while the TS 1170A>G polymorphism displayed a decreasing trend for disease risk when interacting with clinical factors. Furthermore, our results demonstrate the potential contribution of the TS 1100/1170 haplotypes to disease susceptibility, indicating a synergistic interaction with clinical factors in disease occurrence. Based on these findings, we propose that polymorphisms in the 3'-UTR miRNA binding site of the TS gene could serve as clinically useful biomarkers for the prevention, prognosis, and management of CAD.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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